{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:13:34Z","timestamp":1777864414344,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1986,10,1]],"date-time":"1986-10-01T00:00:00Z","timestamp":528508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:p>Dimethicone is a common additive to antacids, although its value in the treatment of reflux oesophagitis is unproven. Its efficacy was assessed by comparing the effect of a dimethicone-containing antacid gel (Asilone Gel) with a simple antacid gel in a double-blind trial in 45 patients with reflux oesophagitis. Thirty-eight patients completed the eight-week course of therapy.<\/jats:p>\n                  <jats:p>Antacid therapy alone resulted in a significant improvement of both symptoms and oesophagitis in gastro-oesophageal reflux. The inclusion of dimethicone in the antacid gel preparation did not confer any benefit in terms of symptomatic assessment but did confer a small advantage with regard to objective markers of oesophageal inflammation, suggesting that a dimethicone-containing antacid is of value in the treatment of symptomatic gastro-oesophageal reflux.<\/jats:p>","DOI":"10.1177\/014107688607901009","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T22:37:04Z","timestamp":1484087824000},"page":"584-587","source":"Crossref","is-referenced-by-count":6,"title":["Does Dimethicone Increase the Efficacy of Antacids in the Treatment of Reflux Oesophagitis?"],"prefix":"10.1177","volume":"79","author":[{"given":"A L","family":"Ogilvie","sequence":"first","affiliation":[{"name":"University Hospital, Queen's Medical Centre, Nottingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Atkinson","sequence":"additional","affiliation":[{"name":"University Hospital, Queen's Medical Centre, Nottingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,10,1]]},"reference":[{"key":"bibr-bibr1-014107688607901009","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1974.tb01382.x"},{"key":"bibr-bibr2-014107688607901009","first-page":"617","volume":"16","author":"Bernstein JE","year":"1974","journal-title":"Current Therapeutic Research"},{"key":"bibr-bibr3-014107688607901009","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1973.tb09963.x"},{"key":"bibr-bibr4-014107688607901009","first-page":"265","volume":"9","author":"James SL","year":"1982","journal-title":"Pharm Act Helv"},{"key":"bibr-bibr5-014107688607901009","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1981.tb11738.x"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688607901009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688607901009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:41:31Z","timestamp":1777527691000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107688607901009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10]]},"references-count":5,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1986,10]]}},"alternative-id":["10.1177\/014107688607901009"],"URL":"https:\/\/doi.org\/10.1177\/014107688607901009","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,10]]}}}