{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:12:49Z","timestamp":1777864369196,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1990,9,1]],"date-time":"1990-09-01T00:00:00Z","timestamp":652147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:p>Fifty-three patients with symptomatic reflux oesophagitis were entered into a single centre randomized study comparing the effects of a dimethicone\/antacid (Asilone Gel) and an alginate\/antacid (Gaviscon liquid) on symptoms and endoscopic changes over an 8-week period. Both treatments significantly improved heartburn, acid regurgitation and flatulence. Dimethicone\/antacid but not alginate\/antacid, produced a significant improvement in oesophagitis, oesophageal ulceration and histological grade of inflammation over the 8-week treatment period so that 14 patients treated with dimethicone\/antacid and 10 with alginate\/antacid had normal endoscopic oesophageal appearances at the end of the study. The difference in improvement between the two patient groups did not reach significance however, except for dimethicone\/antacid improving histological changes (P&lt;0.05). These findings suggest that dimethicone\/antacid and alginate\/antacid are equally effective in treating symptomatic reflux oesophagitis although dimethicone\/antacid may have an advantage in improving oesophageal histological appearances.<\/jats:p>","DOI":"10.1177\/014107689008300907","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T02:09:44Z","timestamp":1519783784000},"page":"554-556","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of a Dimethicone\/Antacid (Asilone Gel) with an Alginate\/Antacid (Gaviscon Liquid) in the Management of Reflux Oesophagitis"],"prefix":"10.1177","volume":"83","author":[{"given":"H L","family":"Smart","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield SIO 2JF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Nottingham, University Hospital, Queen's Medical Centre, Nottingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,9,1]]},"reference":[{"key":"bibr1-014107689008300907","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-1-112"},{"key":"bibr2-014107689008300907","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)92340-X"},{"key":"bibr3-014107689008300907","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197801001-00004"},{"key":"bibr4-014107689008300907","doi-asserted-by":"publisher","DOI":"10.1177\/014107688607901009"},{"key":"bibr5-014107689008300907","first-page":"629","volume":"83","author":"Rokkas T.","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"bibr6-014107689008300907","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1973.tb09963.x"},{"key":"bibr7-014107689008300907","first-page":"153","volume-title":"Cimetidine in the 80s.","author":"Tytgat G.N.J.","year":"1981"},{"key":"bibr8-014107689008300907","first-page":"1392","volume":"90","author":"Dent J.","year":"1986","journal-title":"Gastroenterology"},{"key":"bibr9-014107689008300907","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91726-0"},{"key":"bibr10-014107689008300907","first-page":"61","volume":"1","author":"Branicki F.J.","year":"1988","journal-title":"J Ambulatory Monitoring"},{"key":"bibr11-014107689008300907","doi-asserted-by":"publisher","DOI":"10.1007\/BF01316854"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689008300907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689008300907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:40:44Z","timestamp":1777527644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107689008300907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1177\/014107689008300907"],"URL":"https:\/\/doi.org\/10.1177\/014107689008300907","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}