{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:11:36Z","timestamp":1777864296104,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1990,11,1]],"date-time":"1990-11-01T00:00:00Z","timestamp":657417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:p>Old people are commonly receiving diuretics on admission to hospital. Diuretics are recognized as a risk factor for electrolyte disturbances; controversy exists about the relative risks of different combinations (in particular, co-amilozide [Moduretic]). We recorded the drug history and serum electrolytes in 1000 consecutive admissions to a geriatric hospital, and examined the relative prescribing rates of various diuretics in the community.<\/jats:p>\n                  <jats:p>Full results were obtained in 929 patients. A history of diuretic prescription was present in 353 (38%) of the patients; the mean serum sodium in this group (95% CI 136.0\u2013137.1 mmol\/1) was lower than in the 586 not prescribed diuretics (137.1\u2013137.9 mmol\/1). The difference was small but statistically significant (95% CI difference=0.3\u20131.6 mmol\/1; P&lt;0.01).<\/jats:p>\n                  <jats:p>Hyponatraemia (serum sodium &lt; 130 mmol\/l) was not significantly commoner in the 41 patients prescribed co-amilozide than in patients prescribed other diuretics. In general patients prescribed potassium-retaining diuretics had a lower serum sodium than the others.<\/jats:p>\n                  <jats:p>There was a significant positive correlation between the serum potassium and the log [serum urea) (r=0.26, P &lt; 0.001) and a weak negative correlation existed between sodium and potassium (r= \u22120.14; P &lt; 0.001). There was an association between the prescription of potassium-retaining diuretics and a higher serum potassium; also an association between the prescription of a loop or thiazide diuretic and a lower serum potassium. These interactions were shown by multiple regression analysis to be independent and additive.<\/jats:p>\n                  <jats:p>Co-amilozide formed a significantly higher proportion of all diuretics prescribed in the community group than in the inpatient group (18% versus 12%; P &lt; 0.05).<\/jats:p>\n                  <jats:p>Hyponatraemia was mild and mainly associated with potassium-retaining diuretics in our patients. Our study was unable to confirm or refute any specific dangers of co-amilozide compared with other potassium-retaining diuretic combinations.<\/jats:p>","DOI":"10.1177\/014107689008301111","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T02:18:30Z","timestamp":1519784310000},"page":"704-708","source":"Crossref","is-referenced-by-count":57,"title":["Diuretics and Electrolyte Disturbances in 1000 Consecutive Geriatric Admissions"],"prefix":"10.1177","volume":"83","author":[{"given":"C M","family":"Byatt","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine and St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P H","family":"Millard","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine and St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G E","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,11,1]]},"reference":[{"key":"bibr1-014107689008301111","first-page":"689","volume":"32","author":"Grech E.D.","year":"1987","journal-title":"Modern Medicine"},{"key":"bibr2-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6636.1551"},{"key":"bibr3-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/9.2.73"},{"key":"bibr4-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6567.261"},{"key":"bibr5-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1177\/014107688908200811"},{"key":"bibr6-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/12.1.77"},{"key":"bibr7-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/2.1.14"},{"key":"bibr8-014107689008301111","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1742-1241.1987.tb08489.x","volume":"41","author":"Walters E.G.","year":"1987","journal-title":"Br J Clin Pract"},{"key":"bibr9-014107689008301111","first-page":"65","volume":"42","author":"Miller H.","year":"1987","journal-title":"Geriatrics"},{"key":"bibr10-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/15.6.357"},{"key":"bibr11-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6567.289"},{"key":"bibr12-014107689008301111","first-page":"148","volume":"21","author":"Levy D.W.","year":"1987","journal-title":"J R Coll Physicians Land"},{"key":"bibr13-014107689008301111","unstructured":"RoseD.B. Clinical physiology of acid-base and electrolyte disorders. New York: McGraw-Hill 1989: 392\u20133"},{"key":"bibr14-014107689008301111","unstructured":"Ibid. 606\u20137."},{"key":"bibr15-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90013-9"},{"key":"bibr16-014107689008301111","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-1-24"},{"key":"bibr17-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6641.132-c"},{"key":"bibr18-014107689008301111","doi-asserted-by":"publisher","DOI":"10.1007\/BF00547360"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689008301111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689008301111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:39:38Z","timestamp":1777527578000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107689008301111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["10.1177\/014107689008301111"],"URL":"https:\/\/doi.org\/10.1177\/014107689008301111","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}