{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:14:37Z","timestamp":1777864477344,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1993,5,1]],"date-time":"1993-05-01T00:00:00Z","timestamp":736214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1993,5]]},"abstract":"\n An open, randomized, parallel group study of three different aspirin preparations was carried out. The objective of this study was to compare their ability to inhibit the production of thromboxane A\n 2<\/jats:sub>\n (measured as thromboxane B\n 2<\/jats:sub>\n [TXB\n 2<\/jats:sub>\n ]) from platelets. Three aspirin preparations were studied: Acetard\u00ae 300 mg, Acetard\u00ae 100 mg and Platet\u00ae 100 mg. The study was conducted in 45 healthy adult volunteers and treatment continued once daily for 7 days. The results of the TXB\n 2<\/jats:sub>\n assay show that the administration of all three treatment preparations produced a rapid drop in TXB\n 2<\/jats:sub>\n levels of all volunteers. The baseline TXB\n 2<\/jats:sub>\n level was reduced by 95% for all groups by day 3. Analysis by day showed a significant difference ( P<0.05) between treatments at day 1, with Acetard\u00ae 100 mg having higher TXB\n 2<\/jats:sub>\n levels than the other two groups. Analysis of changes from baseline showed a significant reduction ( P<0.05) in TXB\n 2<\/jats:sub>\n levels at Days 1 to 14 for all three groups. Platelet aggregation also showed a significant reduction, being reduced to 10% of control at 7 days. It then reverted back to baseline by 28 days for all treatment groups. In conclusion, low dose aspirin is very effective as an antiplatelet agent and in a slow release form loses none of its patency.\n <\/jats:p>","DOI":"10.1177\/014107689308600506","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T06:59:15Z","timestamp":1657177155000},"page":"261-263","source":"Crossref","is-referenced-by-count":5,"title":["The Effectiveness of Low Dose Slow Release Aspirin as an Antiplatelet Agent"],"prefix":"10.1177","volume":"86","author":[{"given":"J S","family":"Budd","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P R F","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,5,1]]},"reference":[{"key":"bibr1-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110576"},{"key":"bibr2-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6618.313"},{"key":"bibr3-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6618.320"},{"key":"bibr4-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198304073081402"},{"key":"bibr5-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(82)90065-2"},{"key":"bibr6-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)91658-3"},{"key":"bibr7-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109379"},{"key":"bibr8-014107689308600506","first-page":"1172","author":"Anonymous","year":"1980","journal-title":"Lancet"},{"key":"bibr9-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.8.3.301"},{"key":"bibr10-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197807132990201"},{"key":"bibr11-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6618.307"},{"key":"bibr12-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110313251801"},{"key":"bibr13-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92537-8"},{"key":"bibr14-014107689308600506","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.566"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689308600506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689308600506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:42:33Z","timestamp":1777527753000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107689308600506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.1177\/014107689308600506"],"URL":"https:\/\/doi.org\/10.1177\/014107689308600506","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5]]}}}