{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:15:05Z","timestamp":1777864505443,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1994,10,1]],"date-time":"1994-10-01T00:00:00Z","timestamp":780969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:p>\n                    A retrospective analysis was performed of 48 patients with hyperthyroidism (41 women aged 35\u201380, mean 56.6 years; 7 men aged 31\u201377, mean 52.1 years) treated with a fixed dose of 550 MBq\n                    <jats:sup>131<\/jats:sup>\n                    I during a 12 month period May 1991-April 1992. Weight loss was common at presentation but 28.57% of women aged 35\u201349 years weighed over 80 kg compared to 9.98% in a standard UK population P&gt;0.05. Patients treated with carbimazole (73%) prior to\n                    <jats:sup>131<\/jats:sup>\n                    I had higher FT3 levels at presentation (14.0\u00b14.4 pmol\/l) compared to those (27%) who were considered not to require such treatment (8.9\u00b11.4 pmol\/l, P&gt;0.001).\n                  <\/jats:p>\n                  <jats:p>Four months following radio-iodine, 67% were hypothyroid, 25% were euthyroid and 8% remained thyrotoxic and were retreated. Another patient became hypothyroid during 1 year of follow-up. Pre-treatment with carbimazole did not protect against the development of hypothyroidism (carbimazole treated 69% hypothyroid at 4 months, untreated 62% hypothyroid at 4 months). Patients with continuing thyrotoxicosis had very high FT3 levels at presentation (18.6, 21.1, 20 and in one patient reported only as &gt; 10 pmol\/l). A rationalized programme of follow-up assessments at 2, 3, 4, 8 and 12 months is suggested for patients treated with this dose of radio-iodine.<\/jats:p>","DOI":"10.1177\/014107689408701003","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T09:14:14Z","timestamp":1660814054000},"page":"578-580","source":"Crossref","is-referenced-by-count":5,"title":["Hyperthyroidism and Radio-Iodine Therapy in a District General Hospital"],"prefix":"10.1177","volume":"87","author":[{"given":"D F","family":"Child","sequence":"first","affiliation":[{"name":"Department of Medicine, Maelor Hospital NHS Trust, Wrexham, Clwyd LL13 7TD, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A S S","family":"Mughni","sequence":"additional","affiliation":[{"name":"Department of Medicine, Maelor Hospital NHS Trust, Wrexham, Clwyd LL13 7TD, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Maelor Hospital NHS Trust, Wrexham, Clwyd LL13 7TD, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C P","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Maelor Hospital NHS Trust, Wrexham, Clwyd LL13 7TD, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J N","family":"Harvey","sequence":"additional","affiliation":[{"name":"University of Wales, Department of Medicine, Maelor Hospital NHS Trust, Wrexham, Clwyd LL13 7TD, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,10,1]]},"reference":[{"key":"bibr1-014107689408701003","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2881-8"},{"key":"bibr2-014107689408701003","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6856.727"},{"key":"bibr3-014107689408701003","first-page":"348","volume":"26","author":"Hedley AJ","year":"1992","journal-title":"J R Coll Phys"},{"key":"bibr4-014107689408701003","unstructured":"GregoryJ, FosterK, TylerH, WisemanM. The dietary and nutritional survey of British adults. OPCS Social Survey. London: HMSO, 1990;12:41."},{"key":"bibr5-014107689408701003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1975.tb03052.x"},{"key":"bibr6-014107689408701003","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92071-1"},{"key":"bibr7-014107689408701003","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6441.361"},{"key":"bibr8-014107689408701003","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-59-707-1105"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689408701003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689408701003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:42:57Z","timestamp":1777527777000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107689408701003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1177\/014107689408701003"],"URL":"https:\/\/doi.org\/10.1177\/014107689408701003","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}