{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:09:57Z","timestamp":1777864197901,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>\n                    Bone marrow transplant (BMT) has been used as part of the overall treatment of refractory malignant diseases. High dose cyclophosphamide and total body irradiation (TBI) are frequently used as conditioning for BMT. Initial regimens included a single fraction of TBI, with doses varying from 7.5-1O Gy, but this was associated with a high incidence of late sequelae including multiple endocrinopathies\n                    <jats:sup>1<\/jats:sup>\n                    . A fractionated irradiation course over 3-4 days of a higher total dose, 12-15 Gy, of TBI is now used\n                    <jats:sup>1,2<\/jats:sup>\n                    . Successfully treated patients with childhood cancer have an increased risk, of developing second tumours. We describe a patient successfully treated for AML who developed multiple endocrine dysfunction and a second benign ovarian tumour.\n                  <\/jats:p>","DOI":"10.1177\/014107689608900221","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T01:21:57Z","timestamp":1520472117000},"page":"113P-114P","source":"Crossref","is-referenced-by-count":1,"title":["Secondary Amenorrhoea after Total Body Irradiation in Pre-Puberty"],"prefix":"10.1177","volume":"89","author":[{"given":"A","family":"Albanese","sequence":"first","affiliation":[{"name":"Department of Medical Unit, The Institute of Child Health, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A D","family":"Leiper","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Trust, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Trust, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Stanhope","sequence":"additional","affiliation":[{"name":"Department of Medical Unit, The Institute of Child Health, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,2,1]]},"reference":[{"key":"bibr1-014107689608900221","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1280508"},{"key":"bibr2-014107689608900221","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.9.1107"},{"key":"bibr3-014107689608900221","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-197506000-00017"},{"key":"bibr4-014107689608900221","first-page":"186","volume":"95","author":"Tang M.","year":"1982","journal-title":"Chin Med J"},{"key":"bibr5-014107689608900221","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6842.1601"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689608900221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689608900221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:38:06Z","timestamp":1777527486000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107689608900221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1177\/014107689608900221"],"URL":"https:\/\/doi.org\/10.1177\/014107689608900221","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}