{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:19:11Z","timestamp":1777864751169,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p>Lateral internal sphincterotomy has been the standard treatment for chronic anal fissure, but fissure healing rates of up to 80% with topical glyceryl trinitrate (GTN) treatment have suggested that this operation may become redundant. We evaluated the results of topical treatment of chronic anal fissures with 0.2% GTN for 6 weeks in the outpatient clinical setting, outside the confines of a randomized clinical trial. The role of lateral internal sphincterotomy in the GTN era was also assessed.<\/jats:p>\n                  <jats:p>GTN induced fissure healing in 21 of 49 consecutive patients. Fissures healed spontaneously in 2 patients who discontinued GTN because of headache. Lateral internal sphincterotomy was performed in 26 patients who had persistent symptoms after 6 weeks of GTN therapy. At the 6-week post-sphincterotomy review, all fissures had healed and there were no complications.<\/jats:p>\n                  <jats:p>In this study topical GTN for treatment of chronic anal fissure in the outpatient setting was not as effective as demonstrated in controlled clinical trials. Lateral internal sphincterotomy is still a good therapeutic option, especially in patients not responding to GTN.<\/jats:p>","DOI":"10.1177\/014107689909200406","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T06:06:13Z","timestamp":1496124373000},"page":"186-188","source":"Crossref","is-referenced-by-count":14,"title":["Lateral internal sphincterotomy is not redundant in the era of glyceryl trinitrate therapy for chronic anal fissure"],"prefix":"10.1177","volume":"92","author":[{"given":"M","family":"Jonas","sequence":"first","affiliation":[{"name":"Department of Surgery, Derbyshire Royal Infirmary, Derby DE1 2QY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D N","family":"Lobo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Derbyshire Royal Infirmary, Derby DE1 2QY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Gudgeon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Derbyshire Royal Infirmary, Derby DE1 2QY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"bibr1-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800760504"},{"key":"bibr2-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(96)00017-7"},{"key":"bibr3-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)06090-4"},{"key":"bibr4-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050816"},{"key":"bibr5-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7095.1638"},{"key":"bibr6-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1007\/BF02055444"},{"key":"bibr7-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830614"},{"key":"bibr8-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810949"},{"issue":"3","key":"bibr9-014107689909200406","first-page":"A121","volume":"41","author":"Lund J.N.","year":"1997","journal-title":"Gut"},{"key":"bibr10-014107689909200406","first-page":"A711","volume":"110","author":"Lund J.N.","year":"1996","journal-title":"Gastroenterology"},{"key":"bibr11-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800731123"},{"key":"bibr12-014107689909200406","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800680611"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689909200406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107689909200406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:47:57Z","timestamp":1777528077000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107689909200406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["10.1177\/014107689909200406"],"URL":"https:\/\/doi.org\/10.1177\/014107689909200406","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}