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In real application, system inertia and the system parameters vary in a wide range with variations of wind speeds and disturbances, which substantially degrade the maximum power tracking performance of wind turbine. The MPC design should incorporate the available model information into the ESO to improve the control efficiency. Based on this principle, a model-based MPC with ESO control structure is proposed in this paper. Simulation study is conducted to evaluate the performance of the proposed control strategy. 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