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Administration of corticosteroids via IT injection, via application with a pledget to the round window, or via catheter has been used for this purpose. The frequency of adverse events related to the IT injection of steroids is low, with pain, short-lasting vertigo, otitis media, and tympanic perforations being the most common complications. However, the safety of IT steroid therapy has not yet been established in a randomized clinical trial. In this article, we discuss a group of 11 patients with sensorineural hearing loss who underwent myringotomy and tube placement for home-based dexamethasone instillation and subsequently developed the complication of tympanic membrane perforation. It appears that there is a significantly increased incidence of tympanic membrane perforations in this population.<\/jats:p>","DOI":"10.1177\/014556131109000416","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T15:06:22Z","timestamp":1547046382000},"page":"E21-E27","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Incidence of Tympanic Membrane Perforation after Intratympanic Steroid Treatment through Myringotomy Tubes"],"prefix":"10.1177","volume":"90","author":[{"given":"Amy L.","family":"Rutt","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Detroit Medical Center\/Michigan State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary J.","family":"Hawkshaw","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Drexel University College of Medicine, Philadelphia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Sataloff","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Drexel University College of Medicine, Philadelphia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"bibr1-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.138"},{"key":"bibr2-014556131109000416","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109131486"},{"key":"bibr3-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000185050.69394.48"},{"key":"bibr4-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200311000-00008"},{"key":"bibr5-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00003"},{"key":"bibr6-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000224092.79635.ee"},{"key":"bibr7-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000271672.56554.32"},{"key":"bibr8-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200101000-00005"},{"key":"bibr9-014556131109000416","first-page":"66","volume":"33","author":"Nomura Y.","year":"1984","journal-title":"Adv Otorhinolaryngol"},{"key":"bibr10-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198806001-00002"},{"key":"bibr11-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1159\/000276040"},{"key":"bibr12-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1177\/014556139607500806"},{"issue":"4","key":"bibr13-014556131109000416","first-page":"520","volume":"18","author":"Blakley BW","year":"1997","journal-title":"Am J Otol"},{"key":"bibr14-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.6.582"},{"key":"bibr15-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181585428"},{"key":"bibr16-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318168da7a"},{"key":"bibr17-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701477602"},{"key":"bibr18-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.01.022"},{"key":"bibr19-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1080\/00016480601126952"},{"key":"bibr20-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.03.081"},{"key":"bibr21-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1055\/b-0034-97549"},{"key":"bibr22-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.10.006"},{"key":"bibr23-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00006.2005"},{"key":"bibr24-014556131109000416","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000244191.51560.22"},{"key":"bibr25-014556131109000416","doi-asserted-by":"crossref","unstructured":"FukushimaM, KitaharaT, FuseY,  Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids. 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