{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:27:40Z","timestamp":1777562860656,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>We conducted a prospective crossover study to assess the safety and efficacy of 70 % isopropyl alcohol delivered from a squeezable bottle with a specially designed tip as a weekly irrigant to reduce cerumen accumulation. Twenty patients were divided into 2 groups of 10 (20 ears in each group). The patients in group 1 instilled 70% isopropyl alcohol once a week for 2 months; this was followed by 2 months of no ear cleaning. The patients in group 2 performed the opposite routine. At each visit (0, 2, and 4 mo), cerumen accumulation was graded on a scale of 0 to 4, indicating 0, 25, 50, 75, and 100% occlusion, respectively. After the accumulation was graded, a cerumenectomy was performed. At the initial evaluation, the mean occlusion scores were 3.1 for group 1 and 3.3 for group 2\u2014not a statistically significant difference. After the first 2 months of the study, there was a significant difference in occlusion scores between groups 1 and 2 (0.75 and 1.55, respectively; p (p = 0.38). At study's end, there were also significant differences within each group between occlusion scores obtained during the treatment and nontreatment periods (group 1: p 0.02; group 2: p.<\/jats:p>","DOI":"10.1177\/014556131209100318","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T03:20:15Z","timestamp":1547090415000},"page":"E25-E28","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Prospective Study to Evaluate the efficacy of Isopropyl Alcohol Irrigations to Prevent Cerumen Impaction"],"prefix":"10.1177","volume":"91","author":[{"given":"Herbert","family":"Silverstein","sequence":"first","affiliation":[{"name":"Ear Research Foundation, Sarasota, Fla."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Wycherly","sequence":"additional","affiliation":[{"name":"Ear Research Foundation, Sarasota, Fla."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadiel","family":"Alameda","sequence":"additional","affiliation":[{"name":"Ear Research Foundation, Sarasota, Fla."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Van Ess","sequence":"additional","affiliation":[{"name":"Ear Research Foundation, Sarasota, Fla."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"bibr1-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1177\/014556139807700710"},{"key":"bibr2-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.06.026"},{"key":"bibr3-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00952.x"},{"key":"bibr4-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch082"},{"issue":"10","key":"bibr5-014556131209100318","first-page":"1523","volume":"75","author":"McCarter DF","year":"2007","journal-title":"Am Fam Physician"},{"key":"bibr6-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100147905"},{"issue":"3","key":"bibr7-014556131209100318","first-page":"ORL125","volume":"77","author":"Silverstein H","year":"1973","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"bibr8-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2008.01841.x"},{"key":"bibr9-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1326-8"},{"key":"bibr10-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4572(09)90139-2"},{"key":"bibr11-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1177\/000992289403300103"},{"key":"bibr12-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6401.1260"},{"key":"bibr13-014556131209100318","unstructured":"American Academy of Otolaryngology-Head and Neck Surgery. Earwax. www.entnet.org\/HealthInformation\/earwax.cfm. Accessed Dec. 20, 2011."},{"key":"bibr14-014556131209100318","unstructured":"U.S. Food and Drug Administration. Advice for patients: Ear candles. http:\/\/www.fda.gov\/MedicalDevices\/Safety\/AlertsandNotices\/PatientAlerts\/ucm200896.htm. Updated Feb. 22, 2010. Accessed Dec. 20, 2011."},{"key":"bibr15-014556131209100318","unstructured":"U.S. Food and Drug Administration. Products for drying water-clogged ears. www.fda.gov\/ohrms\/dockets\/98fr\/081000a.txt. Updated Aug. 10, 2000. Accessed Dec. 20, 2011."},{"key":"bibr16-014556131209100318","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108003307"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131209100318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131209100318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:37:42Z","timestamp":1777401462000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014556131209100318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1177\/014556131209100318"],"URL":"https:\/\/doi.org\/10.1177\/014556131209100318","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}