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Because of the limited number of reported cases in the literature, no reliable treatment has been established. We describe the case of a 79-year-old man who presented with a persistent submandibular mass that was suspicious for a malignancy on imaging. Following surgical resection and histopathologic analysis, a diagnosis of poorly differentiated small-cell NEC was made. The patient was further treated with postoperative chemotherapy, and he exhibited no evidence of recurrence or metastasis on follow-up.<\/jats:p>","DOI":"10.1177\/014556131209100416","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T15:07:11Z","timestamp":1547046431000},"page":"E10-E13","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Poorly Differentiated Small-Cell Neuroendocrine carcinoma of the Submandibular Gland: A Case Report"],"prefix":"10.1177","volume":"91","author":[{"given":"Mary","family":"Scaduto","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Cardinal Glennon Children's Medical Center, St. Louis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Matrka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Texas Health Science Center at San Antonio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Medical Center, Columbus."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Paul","family":"Wakely","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Head and Neck Surgery, The Ohio State University Medical Center, Columbus."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enver","family":"Ozer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, The Ohio State University Medical Center, Columbus."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"key":"bibr1-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200903"},{"issue":"3","key":"bibr2-014556131209100416","first-page":"194","volume":"17","author":"Wick MR","year":"2000","journal-title":"Semin Diagn Pathol"},{"key":"bibr3-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880522"},{"key":"bibr4-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.1999.00952.x"},{"key":"bibr5-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1177\/014556131209100211"},{"key":"bibr6-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880096"},{"key":"bibr7-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.06.013"},{"key":"bibr8-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2004.11.016"},{"key":"bibr9-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.06.013"},{"key":"bibr10-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1177\/014556131209100317"},{"key":"bibr11-014556131209100416","first-page":"65","volume":"38","author":"Brooks JS","year":"1996","journal-title":"Monogr Pathol"},{"key":"bibr12-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.10.024"},{"key":"bibr13-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880130605"},{"key":"bibr14-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1177\/030089160709300517"},{"issue":"5","key":"bibr15-014556131209100416","first-page":"392","volume":"48","author":"Frade Gonz\u00e1lez C","year":"1997","journal-title":"Acta Otorrinolaringol Esp"},{"key":"bibr16-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860801)58:3<705::AID-CNCR2820580318>3.0.CO;2-T"},{"key":"bibr17-014556131209100416","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871001)60:7<1583::AID-CNCR2820600728>3.0.CO;2-E"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131209100416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131209100416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:37:46Z","timestamp":1777401466000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014556131209100416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1177\/014556131209100416"],"URL":"https:\/\/doi.org\/10.1177\/014556131209100416","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}