{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:08:28Z","timestamp":1777561708422,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>We report the case of a 31-year-old woman with systemic lupus erythematosus who was found to have oral hairy leukoplakia (OHL). She was on immunosuppressive therapy but was human immunodeficiency virus (HIV)-negative. OHL has been previously reported in HIV-negative patients who were immunosuppressed for other reasons, such as solid organ or hematopoietic stem cell transplantation, hematologic malignancies, or systemic diseases. To the best of our knowledge, this is the first case of OHL in an HIV-negative patient reported in the otolaryngology literature. It adds to the growing list of cases of OHL in HIV-negative patients and serves as a reminder to physicians to include OHL in the differential diagnosis for oral cavity lesions in all immunosuppressed patients. The article also summarizes the current state of knowledge about the pathogenesis of OHL, its relation to the Epstein-Barr virus, and the treatment options.<\/jats:p>","DOI":"10.1177\/014556131309200614","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T15:09:04Z","timestamp":1547046544000},"page":"E12-E15","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Oral Hairy Leukoplakia in an HIV-Negative Patient"],"prefix":"10.1177","volume":"92","author":[{"given":"Evan M.","family":"Graboyes","sequence":"first","affiliation":[{"name":"From the Department of Otolaryngology\u2013Head and Neck Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clint T.","family":"Allen","sequence":"additional","affiliation":[{"name":"From the Department of Otolaryngology\u2013Head and Neck Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca D.","family":"Chernock","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Diaz","sequence":"additional","affiliation":[{"name":"From the Department of Otolaryngology\u2013Head and Neck Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,6,1]]},"reference":[{"key":"bibr1-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90872-9"},{"key":"bibr2-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1177\/1066896908327865"},{"key":"bibr3-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90070-7"},{"key":"bibr4-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90344-P"},{"key":"bibr5-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb01573.x"},{"key":"bibr6-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(87)90174-5"},{"key":"bibr7-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198512193132502"},{"key":"bibr8-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1086\/378072"},{"key":"bibr9-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1086\/323992"},{"key":"bibr10-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00198.x"},{"key":"bibr11-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(05)80076-9"},{"key":"bibr12-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90097-A"},{"issue":"1","key":"bibr13-014556131309200614","first-page":"S50","volume":"103","author":"Baccaglini L","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"bibr14-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.02.016"},{"key":"bibr15-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.11.017"},{"key":"bibr16-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70250-4"},{"key":"bibr17-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03720030044031"},{"issue":"6","key":"bibr18-014556131309200614","first-page":"571","volume":"3","author":"Greenspan D","year":"1990","journal-title":"J Acquir Immune Defic Syndr"},{"key":"bibr19-014556131309200614","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008351"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131309200614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131309200614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:34:25Z","timestamp":1777401265000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014556131309200614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1177\/014556131309200614"],"URL":"https:\/\/doi.org\/10.1177\/014556131309200614","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}