{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:09:42Z","timestamp":1777561782951,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Human papillomavirus 16 (HPV-16) infection and tobacco use are associated with human oropharyngeal cancers. We conducted a study of the role of HPV and tobacco use in base of the tongue (BOT) cancers. DNA from 34 such cancers was subjected to HPV-16 and HPV-18-specific polymerase chain reaction analysis. Demographic and clinicopathologic data were obtained from each patient's medical record. HPV-16 was detected in 68% of tumors. Tobacco use was the only factor found to be significantly associated with HPV status. Tumors from 100% of patients who had never use d tobacco tested positive for HPV, compared with only 56% of those who had ever used tobacco (Fisher exact test, p = 0.024). All tumors were associated with either tobacco use or HPV infection. These findings are consistent with the hypothesis that either tobacco use or HPV infection is necessary to the etiology of BOT tumors, and they suggest that tongue base carcinoma may be prevented by combining HPV vaccination with tobacco avoidance.<\/jats:p>","DOI":"10.1177\/014556131309200812","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T15:08:52Z","timestamp":1547046532000},"page":"372-380","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Human Papillomavirus and Tobacco Use in Tongue Base Cancers"],"prefix":"10.1177","volume":"92","author":[{"given":"Daniel L.","family":"Stoler","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, Roswell Park Cancer Institute, Buffalo, N.Y."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Smaldino","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, N.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huferesh K.","family":"Darbary","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Columbia University Medical Center, New York City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen A.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Cancer Institute, Buffalo, N.Y."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurin R.","family":"Popat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, State University of New York at Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Wesley L.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Roswell Park Cancer Institute, Buffalo, N.Y."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Merzianu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Roswell Park Cancer Institute, Buffalo, N.Y."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Gaile","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, N.Y."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garth R.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, N.Y."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom R.","family":"Loree","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery, Erie County Medical Center, Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,8,1]]},"reference":[{"key":"bibr1-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195711\/12)10:6<1300::AID-CNCR2820100628>3.0.CO;2-2"},{"key":"bibr2-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930815)72:4<1369::AID-CNCR2820720436>3.0.CO;2-L"},{"key":"bibr3-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.09.013"},{"key":"bibr4-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22963"},{"key":"bibr5-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20740"},{"key":"bibr6-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20998"},{"key":"bibr7-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"bibr8-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"bibr9-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065497"},{"key":"bibr10-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.3.405"},{"key":"bibr11-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.116979"},{"key":"bibr12-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20490"},{"key":"bibr13-014556131309200812","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.00.3335"},{"key":"bibr14-014556131309200812","unstructured":"NCIthesaurus. 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