{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:12:01Z","timestamp":1777561921605,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Leiomyosarcoma of the head and neck is very rare, as only about 100 cases have been reported; of these, only 3 cases have been previously reported in the parapharyngeal space. We report the fourth such case, and we review the features of this entity. The patient was an 84-year-old woman who presented to the emergency department for treatment of an 18-month history of right-sided headache, a 6-month history of right-sided hearing loss and nasal obstruction, and a 2-month history of dysphagia. Physical examination revealed a bulge in the right side of the soft palate and the right lateral nasopharyngeal wall and complete obstruction of the right eustachian tube. Indirect laryngoscopy detected a bulge in the right lateral hypopharyngeal wall. Otoscopy revealed otitis media with effusion in the right ear. Imaging demonstrated a space-occupying lesion in the right parapharyngeal space that extended from the base of the skull to the level of the hypopharynx. Biopsy and histology identified the mass as a leiomyosarcoma. Metastasis to the brain was discovered shortly thereafter, and the patient died 10 months later. The unusual presentation of head and neck leiomyosarcoma requires a high index of suspicion and appropriate diagnostic imaging. Surgical excision is the recommended treatment when feasible; chemoradiotherapy does not appear to affect disease progression.<\/jats:p>","DOI":"10.1177\/014556131409300701","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T07:07:54Z","timestamp":1547104074000},"page":"E5-E8","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Leiomyosarcoma of the Parapharyngeal Space: A Very Rare Entity"],"prefix":"10.1177","volume":"93","author":[{"given":"Haim","family":"Gavriel","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Assaf Harofeh Medical Center, Zerifin, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Yeheskeli","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Assaf Harofeh Medical Center, Zerifin, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gratiana","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Pathology, Assaf Harofeh Medical Center, Zerifin, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ephraim","family":"Eviatar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Assaf Harofeh Medical Center, Zerifin, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,7,1]]},"reference":[{"key":"bibr1-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06688-7.00006-7"},{"key":"bibr2-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00814.x"},{"issue":"11","key":"bibr3-014556131409300701","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1001\/archotol.1988.01860230124041","volume":"114","author":"Goldberg SH","year":"1988","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"bibr4-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1177\/014556130508400715"},{"key":"bibr5-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001905698"},{"key":"bibr6-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880140111"},{"key":"bibr7-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2005.01.012"},{"issue":"7","key":"bibr8-014556131409300701","first-page":"E20","volume":"91","author":"Parida PK","year":"2012","journal-title":"Ear Nose Throat J"},{"key":"bibr9-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199006000-00006"},{"key":"bibr10-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2000.9587"},{"issue":"1","key":"bibr11-014556131409300701","first-page":"E61","volume":"13","author":"Fern\u00e1ndez Ferro M","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"bibr12-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.22691"},{"key":"bibr13-014556131409300701","first-page":"491","volume-title":"Soft Tissue Tumors","author":"Enzinger FM","year":"1995"},{"key":"bibr14-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.06.018"},{"key":"bibr15-014556131409300701","doi-asserted-by":"publisher","DOI":"10.1177\/014556130108000710"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131409300701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131409300701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:34:57Z","timestamp":1777401297000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014556131409300701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1177\/014556131409300701"],"URL":"https:\/\/doi.org\/10.1177\/014556131409300701","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}