{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:04:27Z","timestamp":1787018667913,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>The purpose of this retrospective chart review study was to review the nature and clinical course of benign and malignant submandibular gland tumors at 2 major university-affiliated tertiary medical centers. All patients who underwent submandibular salivary gland excision between 1990 and 2010 were included. Clinical and disease-related data were collected from the medical charts. One hundred ninety-three patients were identified, of whom 108 (56%) had non-neoplastic disorders (sialolithiasis and sialadenitis). The remaining 85 patients (44%) had a submandibular salivary gland tumor. The most common benign neoplasm was pleomorphic adenoma (53 patients). Twenty tumors (24%) were malignant: adenoid cystic carcinoma in 11 patients, mucoepidermoid carcinoma in 6 patients, and adenocarcinoma in 3 patients. Recurrence was noted in 7 patients with submandibular gland malignancy and in 2 patients with pleomorphic adenoma. The 5-year disease-free survival rate was 63%. Tumors of the submandibular gland are infrequently malignant. Recurrent submandibular salivary gland pleomorphic adenoma is rare compared with recurrences in the parotid gland.<\/jats:p>","DOI":"10.1177\/014556131709600320","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T08:15:25Z","timestamp":1547021725000},"page":"E17-E20","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Submandibular Salivary Gland Tumors: Clinical Course and Outcome of a 20-Year Multicenter Study"],"prefix":"10.1177","volume":"96","author":[{"given":"Aviram","family":"Mizrachi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Headand Neck Surgery, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Bachar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Headand Neck Surgery, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Unger","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohad","family":"Hilly","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Headand Neck Surgery, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Fliss","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Shpitzer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Headand Neck Surgery, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"bibr1-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197802000-00007"},{"key":"bibr2-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1976.tb01870.x"},{"issue":"1","key":"bibr3-014556131709600320","first-page":"51","volume":"146","author":"Eveson J.W.","year":"1985","journal-title":"A review of 2410 cases with particular reference to histological types, site, age and sex distribution J Pathol"},{"key":"bibr4-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890080309"},{"key":"bibr5-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.02.036"},{"key":"bibr6-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100158323"},{"key":"bibr7-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80546-X"},{"key":"bibr8-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90320-2"},{"key":"bibr9-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(86)80044-9"},{"key":"bibr10-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.03.006"},{"key":"bibr11-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1097\/01.scs.0000249352.43849.04"},{"key":"bibr12-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980401)82:7<1217::AID-CNCR2>3.0.CO;2-C"},{"key":"bibr13-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1002\/jso.10125"},{"key":"bibr14-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178099"},{"key":"bibr15-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199106000-00002"},{"issue":"3","key":"bibr16-014556131709600320","first-page":"191","volume":"40","author":"Pohar S.","year":"2011","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"bibr17-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.09.030"},{"key":"bibr18-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70323-2"},{"key":"bibr19-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198810000-00003"},{"key":"bibr20-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2011.04.008"},{"key":"bibr21-014556131709600320","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2011.05.002"}],"container-title":["Ear, Nose &amp; 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