{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:19:42Z","timestamp":1777562382778,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    There is currently no clear distinction between the treatment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCC). HPV-positive OPSCC has been demonstrated to be more radiosensitive than its HPV-negative counterpart. Despite this, patients with HPV-positive OPSCC continue to receive a full dose of radiation (70 Gy) outside clinical trials. However, this high dose comes with considerable morbidities, including severe mucositis, dysphagia, and xerostomia. We describe the cases of 2 patients with HPV-positive OPSCC who received two cycles of high-dose cisplatin at 100 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    on 3 separate days, along with concurrent radiotherapy at 50 Gy in 25 fractions for one and 46 Gy in 23 fractions for the other. During treatment, both patients experienced significant acute-phase toxicities\u2014including grade 3 mucositis, grade 3 nausea, and grade 2 dermatitis\u2014and their treatment regimen was stopped before its planned completion. Nevertheless, after a follow-up of 75 and 78 months, respectively, neither patient exhibited any evidence of disease. Late toxicities included grade 1 xerostomia, grade 1 pharyngeal-phase dysphagia, and grade 1 dysgeusia with some foods. We conclude that de-escalating the dose of radiation for HPV-positive patients by 30% and identifying which patients can safely be treated with this level of dose reduction warrants further study.\n                  <\/jats:p>","DOI":"10.1177\/014556131709600705","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T23:45:33Z","timestamp":1543967133000},"page":"E23-E27","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Recurrence-Free Survival after an Unplanned Reduction in Radiotherapy for HPV-Positive Oropharyngeal SCC: Two Cases and a Review of the Literature"],"prefix":"10.1177","volume":"96","author":[{"given":"Jason","family":"Liu","sequence":"first","affiliation":[{"name":"Penn State College of Medicine, Hershey, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Hershey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah","family":"Almokadem","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Hershey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Crist","sequence":"additional","affiliation":[{"name":"Division of Pathology, Division of Radiation Oncology, Hershey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heath B.","family":"Mackley","sequence":"additional","affiliation":[{"name":"Penn State Hershey Cancer Institute, Hershey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"key":"bibr1-014556131709600705","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2011.0055"},{"key":"bibr2-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"bibr3-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.12.019"},{"key":"bibr4-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28595"},{"key":"bibr5-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12024"},{"key":"bibr6-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23699"},{"key":"bibr7-014556131709600705","doi-asserted-by":"publisher","DOI":"10.7785\/tcrt.2012.500305"},{"key":"bibr8-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000086"},{"key":"bibr9-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2008.540"},{"issue":"4","key":"bibr10-014556131709600705","first-page":"313","volume":"19","author":"Wierzbicka M.","year":"2015","journal-title":"Contemp Oncol (Pozn)"},{"key":"bibr11-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.159"},{"key":"bibr12-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-014-0605-5"},{"key":"bibr13-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28847"},{"key":"bibr14-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3771-x"},{"key":"bibr15-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-014-0652-y"},{"key":"bibr16-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.11.004"},{"key":"bibr17-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.12.058"},{"key":"bibr18-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.030"},{"key":"bibr19-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2350"},{"key":"bibr20-014556131709600705","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23458"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131709600705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014556131709600705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:36:07Z","timestamp":1777401367000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014556131709600705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1177\/014556131709600705"],"URL":"https:\/\/doi.org\/10.1177\/014556131709600705","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}