{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:50Z","timestamp":1791330950313,"version":"4.3.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>We conducted a prospective study to assess the effectiveness of a platelet-rich plasma hourglass graft in the repair of small tympanic membrane perforations as an office-based procedure. Our study population was made up of 25 patients\u201410 men and 15 women, aged 19 to 45 years (mean: 30.4 \u00b1 7.2)\u2014who each underwent repair of one eardrum. After administration of topical anesthesia, a single piece of platelet-rich plasma approximately double the size of the perforation was obtained from each patient's intravenous blood sample. After the margin of the perforation was freshened, the platelet-rich plasma was placed in an hourglass configuration, with equal portions lying medial and lateral to the perforation. Successful perforation repair was achieved in 21 of the 25 ears (84%). No patient developed an infection, hearing impairment, tinnitus, vertigo, bleeding, taste disturbance, or hyperkeratosis. We conclude that office-based platelet-rich plasma myringoplasty is a safe and effective minimally invasive procedure that is suitable for repairing small tympanic membrane perforations.<\/jats:p>","DOI":"10.1177\/014556131709600818","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T23:45:04Z","timestamp":1543967104000},"page":"312-326","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Platelet-Rich Plasma Myringoplasty: A New Office Procedure for the Repair of Small Tympanic Membrane Perforations"],"prefix":"10.1177","volume":"96","author":[{"given":"Mohammad Waheed","family":"El-Anwar","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Zagazig University Faculty of Medicine, Zagazig, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Elnashar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Zagazig University Faculty of Medicine, Zagazig, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser Ahmad","family":"Foad","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Zagazig University Faculty of Medicine, Zagazig, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,1]]},"reference":[{"key":"bibr1-014556131709600818","volume-title":"Healing of Tympanic Membrane Perforations: An Experimental Study.","author":"Rahman A.","year":"2007"},{"issue":"6","key":"bibr2-014556131709600818","first-page":"318","volume":"27","author":"Imamo\u011flu M.","year":"1998","journal-title":"J 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