{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:17:53Z","timestamp":1777562273264,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>\n                    <jats:italic>Liposarcomas are rare mesenchymal tumors that usually develop in lower\n                        extremities or retroperitoneum; cervico-mediastinal presentation is quite\n                        uncommon. These neoplasms are commonly diagnosed at a late stage because\n                        they remain asymptomatic until nearby structures are compressed. This makes\n                        radical excision particularly challenging. To date, alternative\n                        chemoradiotherapy protocols have not yet been standardized. We report a case\n                        of a 55-year-old man with a right laterocervical mass and without\n                        substantial symptoms. Fine-needle aspiration cytology results were\n                        compatible with a well-differentiated liposarcoma. Contrast-enhanced\n                        magnetic resonance imaging revealed the magnitude of the mass, which was\n                        expanding into the mediastinum; displacing the trachea, esophagus, cervical\n                        neurovascular bundle, and thoracic aorta; and encasing the brachiocephalic\n                        artery. Compression of the left brachiocephalic vein resulted in a focal\n                        enhancement spot in the fourth liver segment, the expression of superior\n                        vena cava compression, which can promote the development of collateral\n                        venous pathways, such as the caval-mammary-phrenic-hepatic capsule-portal\n                        venous pathway. The mass was successfully excised by a team of surgical\n                        subspecialists (otorhinolaryngologists and thoracic, cardiac, and vascular\n                        surgeons). Adjuvant tomotherapy was administered to increase local disease\n                        control. The patient remained disease-free 38 months postoperatively. This\n                        case underlines the importance of accurate pre-operative radiologic\n                        evaluation in patients presenting with neck masses but without substantial\n                        symptoms. Because of the involvement of many critical structures, the\n                        cooperation of many surgical subspecialties is mandatory to achieve a\n                        satisfying oncologic outcome.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1177\/014556131709601213","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T06:00:08Z","timestamp":1603692008000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Multidisciplinary management of a giant cervico-mediastinal                    liposarcoma: A case report and literature review"],"prefix":"10.1177","volume":"96","author":[{"given":"Andrea","family":"Galli","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, San Raffaele\r                Scientific Institute, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leone","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, San Raffaele\r                Scientific Institute, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piergiorgio","family":"Muriana","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, San Raffaele\r                Scientific Institute, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Bandiera","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, San Raffaele\r                Scientific Institute, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampiero","family":"Negri","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, San Raffaele\r                Scientific Institute, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Zannini","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, San Raffaele\r                Scientific Institute, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bussi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, San Raffaele\r                Scientific Institute, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"207","article-title":"Lipomatous tumors.","volume":"38","author":"Weiss S.W.","year":"1996","unstructured":"WeissS.W. Lipomatous tumors. Monogr Pathol 1996; 38: 207\u201339.","journal-title":"Monogr Pathol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-011-0013-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22239"},{"issue":"6","key":"e_1_2_1_5_2","first-page":"407","article-title":"Recurrent mediastinal liposarcoma twenty years after the initial\n                        operation: Case report.","volume":"13","author":"Matsubara H.","year":"2007","unstructured":"MatsubaraH., MizutaniE., OkuwakiH. Recurrent mediastinal liposarcoma twenty years after the initial operation: Case report. Ann Thorac Cardiovasc Surg 2007; 13(6): 407\u20139.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm0912793"},{"key":"e_1_2_1_7_2","unstructured":"GoldblumJ.R. FolpeA.L. WeissS.M. Liposarcoma. In: GoldblumJ.R. FolpeA.L. WeissS.W. Enzinger and Weiss's Soft Tissue Tumors. 6th ed. NY: Elsevier Saunders; 2014: 484\u2013523."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00265-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318093f925"},{"issue":"4","key":"e_1_2_1_10_2","first-page":"405","article-title":"Clinical analysis of 19 cases of adult primary mediastinal\n                        liposarcoma.","volume":"34","author":"Su K.","year":"2012","unstructured":"SuK., ChengG.Y., LiuX.Y. Clinical analysis of 19 cases of adult primary mediastinal liposarcoma. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2012; 34(4): 405\u20138.","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182562bc1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-008-0329-5"},{"issue":"1","key":"e_1_2_1_13_2","first-page":"38","article-title":"Surgical resection of primary liposarcoma of the anterior\n                        mediastinum.","volume":"14","author":"Hirai S.","year":"2008","unstructured":"HiraiS., HamanakaY., MitsuiN. Surgical resection of primary liposarcoma of the anterior mediastinum. Ann Thorac Cardiovasc Surg 2008; 14(1): 38\u201341.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1039056"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2008.04.001"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.05.007"},{"issue":"3","key":"e_1_2_1_17_2","first-page":"140","article-title":"Soft tissue liposarcoma: Histological subtypes, MRI and CT\n                        findings.","volume":"104","author":"Barile A.","year":"2002","unstructured":"BarileA., ZugaroL., CatalucciA. Soft tissue liposarcoma: Histological subtypes, MRI and CT findings. 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