{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:21:36Z","timestamp":1777562496601,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>The etiology of M\u00e9ni\u00e8re disease (MD) is multifactorial; genetic factors seem to play an important role. The associations between MD and human leukocyte antigen (HLA) status have been studied previously in several populations and have shown that the HLA alleles imparting susceptibility varied. In the present study, we explored HLA status in Taiwanese patients with definitive MD. HLA was typed via polymerase chain reaction, sequence-specific oligonucleotide genotyping in 35 patients with MD diagnosed using the criteria of the American Academy of Otolaryngology\u2013Head and Neck Surgery and 70 unrelated healthy controls. HLA allele association tests were used to evaluate differences in allelic frequencies between the patients and controls. The allelic frequency of HLA-A\u221711 was significantly greater in MD patients than in controls (52.9 vs. 31.4%, odds ratio: 2.45, 95% confidence interval: 1.4 to 4.4, p = 0.004, p corrected = 0.03). Thus, A\u221711 may be a useful HLA biomarker in Taiwanese patients with MD. Further larger-scale studies are required.<\/jats:p>","DOI":"10.1177\/014556131809701208","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T05:39:28Z","timestamp":1551073168000},"page":"396-402","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of M\u00e9ni\u00e8re Disease with Human Leukocyte Antigen in Taiwanese Population"],"prefix":"10.1177","volume":"97","author":[{"given":"Kai-Chieh","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Otology, Department of Otolaryngology Chang Gung Memorial Hospital, Linkou, Taiwan"},{"name":"Graduate institute of Clinical Medical Science, Chang Gung Memorial Hospital, Linkou, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che-Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of 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