{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:43:35Z","timestamp":1788911015668,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"2017 Youth Project, which is funded by Fujian Provincial Health and Family Planning Commission","award":["2017-1-52"],"award-info":[{"award-number":["2017-1-52"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>To investigate the application of inner ear 3-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI) in patients with sudden sensorineural hearing loss (SSNHL) accompanied by inner ear hemorrhage. A total of 1252 SSNHL patients who were admitted from January 2010 to April 2018 were included in the study. The patients\u2019 clinical features, complete blood counts, coagulation profiles, audiometry data, and MRI scans were retrospectively reviewed. Twenty-four patients had high labyrinth signals on inner ear 3D-FLAIR MRI (24\/1252, 1.9%) that were diagnosed as inner ear hemorrhage. One patient had endolymphatic hydrops on the contralesional side. In the 24 patients, pure tone audiometry curves revealed profound deafness (19\/24) and flat moderate hearing loss (5\/24); most patients had associated vertigo (23\/24) and tinnitus (19\/24). Patients with SSNHL (N = 24) were treated. Sixteen patients had invalid improvement, 3 patients were markedly improved, 4 patients had effective treatment, and only 1 patient was cured, for a therapeutic efficacy of 33.3% (8\/24). Follow-up 3D-FLAIR MRI in patients showed absorbance of labyrinthine hemorrhage and disappearance of the high signal intensity in the inner ear within 2 weeks to 4 months. Inner ear 3D-FLAIR MRI indicate that most cases of inner ear hemorrhage are spontaneous and that high labyrinth signals are absorbed within 4 months. The site of labyrinth hemorrhage is irregular and independent of hearing loss. Conventional treatment is not very effective, and an appropriate therapy for SSNHL requires further investigation.<\/jats:p>","DOI":"10.1177\/0145561319834862","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T03:12:13Z","timestamp":1553569933000},"page":"E13-E20","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["The Natural History of Labyrinthine Hemorrhage in Patients With Sudden Sensorineural Hearing Loss"],"prefix":"10.1177","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-8542","authenticated-orcid":false,"given":"Xi-Hang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Taijiang District, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Jun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Taijiang District, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Ming","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Radiology, First Affiliated Hospital of Fujian Medical University, Taijiang District, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Taijiang District, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Mei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Taijiang District, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Taijiang District, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,26]]},"reference":[{"key":"bibr1-0145561319834862","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812436449"},{"issue":"6","key":"bibr2-0145561319834862","first-page":"443","volume":"50","author":"Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; 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