{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:26:01Z","timestamp":1777562761323,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Ocular and ophthalmological adverse effects may be seen in \u03b2-thalassemia major (BTM) patients treated with regular blood transfusions and iron-chelating agents. We hypothesized that olfactory dysfunction may be present in this population. In this study, we aimed to investigate olfactory dysfunction in patients with BTM and determine the etiological factors. A total of 43 patients with BTM were included in the study. Forty-three patients without any nasal complaints, history of facial trauma, or nasal surgery were included as the controls. All participants had nasal endoscopy. The iron-chelating agents used, their duration of use, as well as hemoglobin and ferritin levels of the BTM patients were recorded. Sniffin\u2019 Sticks test (SST) was used to assess olfactory functions, and BTM and control groups were compared for the results. The correlations of SST scores with the other study parameters were analyzed. Eight (18.6%) of 43 patients in the BTM group had hyposmia while none of the patients in the control group had hyposmia ( P &lt; .001). Older age, low-hemoglobin level, and longer use of deferoxamine were found to be correlated with olfactory dysfunction. Olfactory dysfunction may be seen in BTM patients treated with iron-chelating agents. The results of this study suggest that screening for olfactory function may be needed in routine follow-up of BTM patients.<\/jats:p>","DOI":"10.1177\/0145561319840079","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:53:01Z","timestamp":1559177581000},"page":"NP125-NP130","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Olfactory Dysfunction in \u03b2 Thalassemia Major Patients Treated With Iron-Chelating Agents"],"prefix":"10.1177","volume":"98","author":[{"given":"Serhan","family":"Derin","sequence":"first","affiliation":[{"name":"Departments of Otorhinolaryngology, Mugla Sitki Kocman University, Mugla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvet","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Medical Faculty, ENT Department, Kocaeli University, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Sahan","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology, Mugla Sitki Kocman University, Mugla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Fatih","family":"Azik","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Hematology and Oncology, Mugla Sitki Kocman University, Mugla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Derin","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neurology, Necmettin Erbakan University, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasar","family":"Topal","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, Mugla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Topal","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, Mugla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"bibr1-0145561319840079","first-page":"1015","volume-title":"Nathan and Oski\u2019s Hematology of Infancy and Childhood","author":"Cunnigham MJ","year":"2009","edition":"7"},{"key":"bibr2-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1080\/08880010802234911"},{"key":"bibr3-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1159\/000064748"},{"key":"bibr4-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000194019.95096.b6"},{"key":"bibr5-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200103000-00009"},{"key":"bibr6-0145561319840079","first-page":"101","volume":"4","author":"Chaudhary P","year":"2013","journal-title":"J Blood Med"},{"key":"bibr7-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-37250-6_10"},{"key":"bibr8-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"bibr9-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0173-0"},{"key":"bibr10-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2000.0722"},{"key":"bibr11-0145561319840079","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2015.1046185"},{"key":"bibr12-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80556-6"},{"key":"bibr13-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72914-9"},{"key":"bibr14-0145561319840079","doi-asserted-by":"publisher","DOI":"10.1042\/bj2460725"},{"key":"bibr15-0145561319840079","doi-asserted-by":"crossref","unstructured":"Doty RL. 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