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This PROSPERO-registered study aims to review the diagnostic methods, treatment regimens, and survival outcomes for patients with synovial sarcoma of the larynx. A systematic search of databases Medline, Embase, SCOPUS, and Web of Science was undertaken in December 2017. The literature search identified 1031 potentially relevant studies, and after the deletion of duplicates and excluded papers, 98 full-text articles were screened. A total of 39 cases were reviewed from 32 studies in the data extraction. The average age at the time of laryngeal synovial sarcoma diagnosis was 32 years (range, 11-79 years). In all cases (n = 39), patients underwent wide surgical excision, with 20 patients requiring a partial or total laryngectomy. A total of 18 patients received adjuvant and 3 received neoadjuvant radiotherapy. Chemotherapy was used in 10 cases, with ifosfamide the most frequently used agent. There was considerable variability in the order and combinations of the abovementioned treatments. No clinicopathologic factors or treatment regimens were associated with improved overall survival or lower rate of recurrence. There is a paucity of literature and heterogeneity in clinical approaches to this highly aggressive sarcoma. Reporting of cases must be standardized and formal guidelines must be established to guide clinical management.<\/jats:p>","DOI":"10.1177\/0145561319850697","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T06:47:00Z","timestamp":1563259620000},"page":"NP93-NP104","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Laryngeal Synovial Sarcoma: A Systematic Review of the Last 40 Years of Reported Cases"],"prefix":"10.1177","volume":"100","author":[{"given":"Gregory","family":"Shein","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Prince of Wales Hospital, Randwick, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurfateh","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Prince of Wales Hospital, Randwick, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Loo","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Prince of Wales Hospital, Randwick, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Prince of Wales Hospital, Randwick, Sydney, New South Wales, Australia"},{"name":"Department of Otolaryngology, Sydney Children\u2019s Hospital, Randwick, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Anazodo","sequence":"additional","affiliation":[{"name":"Kids Cancer Centre, Sydney Children\u2019s Hospital, Sydney, New South Wales, Australia"},{"name":"Nelune Cancer Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia"},{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"bibr1-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-005-0024-z"},{"key":"bibr2-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930540206"},{"key":"bibr3-0145561319850697","volume-title":"Paper presented at: Anales Otorrinolaringologicos Ibero-Americanos","author":"Herrero JL","year":"1998"},{"key":"bibr4-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2012.07.011"},{"key":"bibr5-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980301392-5"},{"key":"bibr6-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.03230.x"},{"issue":"1","key":"bibr7-0145561319850697","first-page":"32","volume":"36","author":"Grayson W","year":"1998","journal-title":"S Afr J Surg"},{"key":"bibr8-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1975.00780390047013"},{"issue":"5","key":"bibr9-0145561319850697","first-page":"448","volume":"80","author":"Miller LH","year":"1975","journal-title":"Trans Sect Otolaryngol Am Acad Ophthalmol Otolaryngol"},{"key":"bibr10-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2014.09.002"},{"key":"bibr11-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000198"},{"key":"bibr12-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-009-9209-0"},{"issue":"2","key":"bibr13-0145561319850697","first-page":"149","volume":"95","author":"Turki S","year":"2017","journal-title":"Tunis Med"},{"key":"bibr14-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2017.06.007"},{"key":"bibr15-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6134845"},{"key":"bibr16-0145561319850697","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12889"},{"issue":"7","key":"bibr17-0145561319850697","first-page":"7913","volume":"10","author":"Feng J","year":"2017","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr18-0145561319850697","doi-asserted-by":"crossref","unstructured":"Kakkar A, Banerjee D, Kane SV, Rekhi B, Sridhar E. 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