{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:26:06Z","timestamp":1777562766331,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Previous studies suggested that hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) plays an important role in the progression of inflammation and remodeling of chronic rhinosinusitis with nasal polyposis. However, the molecule mechanisms of HIF-1\u03b1 activation and regulation of cytokine expressions, such as interleukin (IL) 25 and IL-17RB, in nasal polyposis are not clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>The IL-25 and IL-17RB levels in human nasal epithelial cells after stimulation by lipopolysaccharide (LPS) were detected by enzyme-linked immunosorbent assay method, and the proteins of HIF-1\u03b1 and p-Akt were detected by Western blot method. Moreover, we evaluated the cytokine levels in the nasal mucosa of a murine model of nasal polyposis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The levels of IL-25 and IL-17RB showed dose- and time-dependent release in response to LPS stimulation. The proteins of HIF-1\u03b1 and p-Akt were both increased significantly after LPS stimulation. After inhibition of PI3K\/Akt pathway by PI3K inhibitor LY294002, the levels of IL-25 and IL-17RB and HIF-1\u03b1 were decreased by LPS stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Inhibition of PI3K or HIF-1\u03b1 pathway could significantly reduce growth factor production and decrease nasal inflammation. The HIF-1\u03b1 pathway could be a novel therapeutic approach for reducing nasal airway inflammation and remodeling in nasal polyposis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0145561319857697","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T01:50:37Z","timestamp":1567043437000},"page":"NP43-NP49","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["The PI3K-Akt-HIF-1\u03b1 Pathway Reducing Nasal Airway Inflammation and Remodeling in Nasal Polyposis"],"prefix":"10.1177","volume":"100","author":[{"given":"Fei","family":"He","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Bayi Hospital affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaigang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhangqiu District People\u2019s Hospital of Ji\u2019nan, Ji\u2019nan, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Bayi Hospital affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"bibr1-0145561319857697","first-page":"1","volume":"20","author":"Fokkens W","year":"2007","journal-title":"Rhinol Suppl"},{"key":"bibr2-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24418"},{"key":"bibr3-0145561319857697","doi-asserted-by":"publisher","DOI":"10.3390\/medicina44040033"},{"key":"bibr4-0145561319857697","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3284"},{"key":"bibr5-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01225.x"},{"issue":"1","key":"bibr6-0145561319857697","first-page":"65","volume":"48","author":"Agius AM","year":"2010","journal-title":"Rhinology"},{"key":"bibr7-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939948"},{"key":"bibr8-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048618"},{"key":"bibr9-0145561319857697","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.1.443"},{"key":"bibr10-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00243-6"},{"key":"bibr11-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2104"},{"key":"bibr12-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.04.045"},{"key":"bibr13-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.038"},{"key":"bibr14-0145561319857697","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.463"},{"key":"bibr15-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0304OC"},{"key":"bibr16-0145561319857697","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901666"},{"key":"bibr17-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2817"},{"key":"bibr18-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02594.x"},{"key":"bibr19-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081773"},{"key":"bibr20-0145561319857697","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12125"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0145561319857697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0145561319857697","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0145561319857697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:37:24Z","timestamp":1777401444000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0145561319857697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,28]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/0145561319857697"],"URL":"https:\/\/doi.org\/10.1177\/0145561319857697","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,28]]}}}