{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:47:53Z","timestamp":1788544073786,"version":"build-2803163510"},"reference-count":20,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>M\u00e9ni\u00e8re disease is a disorder of the inner ear, characterized by rotational vertigo, hearing loss, tinnitus, and vegetative symptoms. The aim of the present research is to examine the effectiveness of betahistine and piracetam in the reduction of vertigo attacks in M\u00e9ni\u00e8re disease. To verify our hypothesis, 105 (31 male and 74 females, mean age [standard deviation], 57.4 [11.05]) adult patients with definite M\u00e9ni\u00e8re disease were enrolled in this investigation. Beside the analysis of the hospital records, the subjective complaints of the patients and the completed vertigo diaries were taken into consideration too. The statistical analysis was completed using the IBM SPSS version 24 software. Retrospective analysis, including a 12 years period was conducted. Based on our results, betahistine was successful in the reduction of attacks. Statistically significant decrease was achieved in frequency of dizziness ( P = .000331) and vertigo ( P &lt; .00001) and in the duration of them ( P = .000098), although in the mean power of them was not ( P = .0887). The mean dose in the symptomatic treatment was determined as 87.5 \u00b1 27.2 mg per day; however, there was no connection detected between the dose of the agent and the effectiveness of the symptomatic control. By using dual therapy (betahistine and piracetam), vertigo episodes appeared significantly less often ( P = .027, Odds ratio: 4.9, 95% confidence interval: 1.2-20.2). Finally, it can be concluded that betahistine is effective in M\u00e9ni\u00e8re disease, but the daily dose of it should be set up for every patient individually. The advantage of the dual therapy was also confirmed.<\/jats:p>","DOI":"10.1177\/0145561319881838","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T08:50:45Z","timestamp":1571215845000},"page":"536-542","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Conservative Treatment Possibilities of M\u00e9ni\u00e8re Disease, Involving Vertigo Diaries"],"prefix":"10.1177","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-5166","authenticated-orcid":false,"given":"Andr\u00e1s","family":"Moln\u00e1r","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Maihoub","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Tam\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Szirmai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"bibr1-0145561319881838","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2019.1658898"},{"key":"bibr2-0145561319881838","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-793"},{"key":"bibr3-0145561319881838","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3126w"},{"key":"bibr4-0145561319881838","doi-asserted-by":"publisher","DOI":"10.3233\/VES-2012-0453"},{"key":"bibr5-0145561319881838","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.05.001"},{"key":"bibr6-0145561319881838","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2017.1373850"},{"key":"bibr7-0145561319881838","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-015-0341-x"},{"key":"bibr8-0145561319881838","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109121143"},{"key":"bibr9-0145561319881838","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039086"},{"key":"bibr10-0145561319881838","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01795-8"},{"key":"bibr11-0145561319881838","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00431"},{"key":"bibr12-0145561319881838","unstructured":"Szirmai A. 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