{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:30:03Z","timestamp":1777570203547,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"5_suppl","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare the 2 long-term medical strategies in chronic rhinosinusitis without nasal polyps (CRSnNP) and to identify the role of gastroesophageal reflux disease (GERD) and Helicobacter pylori as factors of treatment failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Fifty-seven patients with CRSnNP were randomized into 2 therapeutic groups. The first group was treated with 4 weeks of amoxicillin\/clavulanate and a short course of oral steroids. The second group received 8 weeks of clarithromycin. Sinonasal Outcome Test-20 (SNOT-20) and Lund and Mackay scores were assessed at baseline and after treatment, and GERD Health-Related Quality of Life (GERD-HRQL) questionnaire was evaluated in all patients. Patients with a GERD-HRQL score &gt;8 received esogastroscopy and H pylori detection. Patients were followed during a 10-year period for clinical course and GERD evolution. The 10-year evolution of patients was described in terms of recurrence, medical, and surgical treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirty-seven patients completed the study; SNOT-20 and Lund and Mackay scores similarly improved in both groups. Amoxicillin\/clavulanate group had significantly more adverse reactions than the clarithromycin group (P = .03). After the therapeutic course, 35% (amoxicillin\/clavulanate) and 41% (clarithromycin) of patients needed functional endoscopic sinus surgery (FESS). During the long-term follow-up, 54% (amoxicillin\/clavulanate) and 40% (clarithromycin) of patients had late CRSnNP recurrence; FESS was performed in less than 15% of cases of recurrence. Gastroesophageal reflux disease complaint\u2019s severity was associated with late recurrence of CRSnNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Amoxicillin\/clavulanate and clarithromycin would be competitive treatments for CRSnNP. Gastroesophageal reflux disease seems to be a negative factor for treatment response and recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0145561319892460","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T01:01:17Z","timestamp":1576458077000},"page":"569S-577S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["A 10-Year Follow-Up of a Randomized Prospective Study of 2 Treatments for Chronic Rhinosinusitis Without Nasal Polyps and Investigation of the Impact of Gastroeosophageal Reflux Disease in the Resistance to Treatment"],"prefix":"10.1177","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, CHU Saint-Pierre, School of Medicine, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium, Europe"},{"name":"Department of Anatomy and Experimental Oncology, Mons School of Medicine, University of Mons, Mons, Belgium, Europe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gersende","family":"Debie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, CHU Saint-Pierre, School of Medicine, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium, Europe"},{"name":"Department of Otolaryngology, Head and Neck Surgery, CHU Saint-Luc, School of Medicine, Universit\u00e9 Catholique de Louvain, Bruxelles, Belgium, Europe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Mahillon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, CHU Saint-Pierre, School of Medicine, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium, Europe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Paule","family":"Thill","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, CHU Saint-Pierre, School of Medicine, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium, Europe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, CHU Saint-Pierre, School of Medicine, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium, Europe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Horoi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, CHU Saint-Pierre, School of Medicine, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium, Europe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stelianos","family":"Kampouridis","sequence":"additional","affiliation":[{"name":"Department of Radiology, CHU Saint-Pierre, School of Medicine, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium, Europe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinciane","family":"Muls","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Saint-Pierre, School of Medicine, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium, Europe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, CHU Saint-Pierre, School of Medicine, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium, Europe"},{"name":"Department of Anatomy and Experimental Oncology, Mons School of Medicine, University of Mons, Mons, Belgium, 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