{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:29:55Z","timestamp":1787869795358,"version":"build-2784847793"},"reference-count":26,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the indications, efficacy, safety, and outcomes of potassium-titanyl-phosphate (KTP) laser procedures for treatment of laryngeal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PubMed, Cochrane Library, and Scopus were searched for studies providing information about the indications, efficacy, and safety of both in-office and operative suspension microlaryngoscopy KTP laser procedure in treatment of laryngeal disease. Diagnostic criteria and clinical outcome evaluation of included studies were analyzed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the initial screened 140 papers, 17 met our inclusion criteria. Six papers involved KTP laser procedures for benign and malignant vocal fold lesions in suspension microlaryngoscopy only, 10 papers focused on only in-office KTP laser procedures for benign vocal fold lesions, and 1 paper included both in-office and suspension microlaryngoscopy procedures. The following lesions may be considered as indications for KTP laser procedures: Reinke\u2019s edema, sulcus vocalis, vocal fold hemorrhage, polyp, granuloma, cyst, scar, papillomatosis, dysplasia, leukoplakia, and early vocal fold malignancies. Irrespective of the types of procedure (in-office vs suspension microlaryngoscopy), the KTP laser is associated with a low complication rate and overall good vocal fold vibration recovery. There is an important heterogeneity among studies concerning laser settings, indications, and outcomes used for the assessment of treatment effectiveness. There are no controlled studies directly comparing KTP laser with other lasers (ie, carbon dioxide laser).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The use of KTP laser procedures for treatment of laryngeal disease has increased over the past decade, especially for office-based management of vocal fold lesions. Future controlled studies are needed to compare the safety and outcomes of the KTP laser to other techniques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0145561319899183","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T04:23:48Z","timestamp":1578889428000},"page":"4S-13S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["The Use of 532-Nanometer-Pulsed Potassium-Titanyl-Phosphate (KTP) Laser in Laryngology: A Systematic Review of Current Indications, Safety, and Voice Outcomes"],"prefix":"10.1177","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Laryngology Study Group of Young-Otolaryngologists, International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France"},{"name":"Department of Human Anatomy and Experimental Oncology, School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium"},{"name":"Department of Otolaryngology-Head Neck Surgery, Foch Hospital, UFR Simone Veil, University Versailles Saint-Quentin en Yvelines (University Paris Saclay), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee M.","family":"Akst","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"bibr1-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500905"},{"key":"bibr2-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31816902bb"},{"key":"bibr3-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200610"},{"key":"bibr4-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500802"},{"key":"bibr5-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21354"},{"key":"bibr6-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2012.04.003"},{"key":"bibr7-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414549155"},{"key":"bibr8-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26445"},{"key":"bibr9-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415619177"},{"key":"bibr10-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-7-16"},{"key":"bibr11-0145561319899183","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"bibr12-0145561319899183","unstructured":"Viswanathan M, Berkman ND, Dryden DM, Hartling L. 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