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And there are few reports of patients treated by an induction chemotherapy (IC) and concurrent chemoradiotherapy (CCRT) approach. This report describes 3 cases of advanced stage LEC of the salivary gland. All patients presented with a palpable mass of variable duration and underwent induction CCRT. All cases were positive for Epstein-Barr virus\u2013encoded small RNAs. After IC, all cases had reached partial response and all achieved complete response after CCRT. All patients remained local\u2013regional recurrence-free after 6-month follow-up for case 1, 50-month for case 2, and 14-month for case 3 up to our last follow-up. No serious adverse events were found.<\/jats:p>","DOI":"10.1177\/0145561320923170","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T02:26:14Z","timestamp":1588904774000},"page":"NP402-NP406","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Is Surgery an Inevitable Treatment for Advanced Salivary Lymphoepithelial Carcinoma? Three Case Reports"],"prefix":"10.1177","volume":"100","author":[{"given":"Shaowen","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"VIP Department, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8888-8694","authenticated-orcid":false,"given":"Yong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"issue":"9","key":"bibr1-0145561320923170","first-page":"1305","volume":"36","author":"Huali MA","year":"2014","journal-title":"Head Neck"},{"key":"bibr2-0145561320923170","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2016.12.010"},{"key":"bibr3-0145561320923170","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2018.250"},{"issue":"6","key":"bibr4-0145561320923170","first-page":"512","volume":"4","author":"Muthayam SR","year":"2014","journal-title":"Quant Imaging Med Surg"},{"key":"bibr5-0145561320923170","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30410-7"},{"key":"bibr6-0145561320923170","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24215"},{"key":"bibr7-0145561320923170","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/17905092"},{"key":"bibr8-0145561320923170","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2018.09.017"},{"key":"bibr9-0145561320923170","doi-asserted-by":"publisher","DOI":"10.3233\/XST-17347"},{"key":"bibr10-0145561320923170","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006115"},{"key":"bibr11-0145561320923170","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2755"},{"key":"bibr12-0145561320923170","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.04.030"},{"issue":"11","key":"bibr13-0145561320923170","first-page":"7951","volume":"7","author":"Zhao W","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr14-0145561320923170","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20312"},{"key":"bibr15-0145561320923170","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-004-1072-7"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0145561320923170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0145561320923170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0145561320923170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:38:21Z","timestamp":1777401501000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0145561320923170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,7]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/0145561320923170"],"URL":"https:\/\/doi.org\/10.1177\/0145561320923170","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,7]]}}}