{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:32:47Z","timestamp":1777563167612,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T00:00:00Z","timestamp":1593907200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      Transoral CO\n                      <jats:sub>2<\/jats:sub>\n                      laser therapy represents the treatment of choice for early-stage laryngeal tumors. The anterior commissure involvement (ACI) is related to a worse local control and a lower rates of organ preservation. The objective of this study is to analyze the differences in survival, local control, and organ preservation in T1b glottic patients according to the presence of ACI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Observational prospective study in pT1b treated with transoral CO\n                      <jats:sub>2<\/jats:sub>\n                      laser between 2009 and 2014.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Forty patients (37 male and 3 female) with a mean age of 66.43 \u00b1 8.16 years were recruited. Anterior commissure involvement was present in 70% of the patients. The 5-year specific cause survival was 91.66%, with 32.50% of local recurrences. Laryngeal preservation was 80%, being lower in the group with local recurrence ( P &lt; .000). The involvement of the anterior commissure does not influence the organ preservation ( P = .548), the appearance of local recurrences ( P = .391), or the survival ( P = .33).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Transoral CO\n                      <jats:sub>2<\/jats:sub>\n                      laser therapy is an effective and reproducible treatment for early-stage laryngeal tumors. The results obtained are similar to previous studies, although they present discrepancies in relation to the role of the ACI. Prospective randomized trials are required focusing also on the patients\u2019 quality of life and functional outcome in order to clarify the role of the ACI and the need to implement changes in its evaluation, staging, and evolution.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0145561320937238","type":"journal-article","created":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T21:31:57Z","timestamp":1593984717000},"page":"68S-72S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["T1b Glottic Tumor and Anterior Commissure Involvement: Is the Transoral CO\n                    <sub>2<\/sub>\n                    Laser Microsurgery a Safe Option?"],"prefix":"10.1177","volume":"100","author":[{"given":"Juan Antonio","family":"Cabrera-Sarmiento","sequence":"first","affiliation":[{"name":"Otorhinolaryngology\u2013Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), Galicia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"V\u00e1zquez-Barro","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology\u2013Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), Galicia, Spain"},{"name":"School of Educational Sciences and Speech Therapy, Universidade da Coru\u00f1a (UDC), A Coru\u00f1a, Galicia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas Herranz","family":"Gonz\u00e1lez-Botas","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology\u2013Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), Galicia, Spain"},{"name":"School of Medicine and Odontology, Universidade de Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-9464","authenticated-orcid":false,"given":"Carlos","family":"Chiesa-Estomba","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology\u2013Head and Neck Surgery Department, Hospital Universitario Donostia, Euskadi, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-6597","authenticated-orcid":false,"given":"Miguel","family":"Mayo-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology\u2013Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), Galicia, Spain"},{"name":"Clinical Research in Medicine, International Center for Doctorate and Advanced Studies (CIEDUS), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,5]]},"reference":[{"key":"bibr1-0145561320937238","unstructured":"Laryngeal and Hypopharyngeal Cancer\u2014Statistics [Internet]. Cancer Net. 2012. Accessed May 13, 2020. https:\/\/www.cancer.net\/cancer-types\/laryngeal-and-hypopharyngeal-cancer\/statistics"},{"key":"bibr2-0145561320937238","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000236095.97947.26"},{"key":"bibr3-0145561320937238","unstructured":"Amin MB, Edge S, Greene F, et al. AJCC Cancer Staging Manual [Internet]. 8th ed. Springer International Publishing; 2017. 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