{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:33:36Z","timestamp":1777563216337,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3_suppl","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81300830"],"award-info":[{"award-number":["81300830"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>We report a 6-year-old girl with progressive bilateral conductive hearing loss for 2 years. She passed the newborn hearing screening conducted with otoacoustic emissions testing and had a normal development of speech and language, which indicated that her deafness was delayed-onset. She also had congenital proximal interphalangeal joints. Proximal symphalangism was confirmed by genetic testing ( NOG gene: c.406C &gt; T, p.R136C). Bilateral stapes ankyloses were proved by surgery and her hearing was improved after stapedotomy by over 30 dB. Besides, this case should remind clinicians to carefully distinguish NOG gene-related deafness from congenital ossicular malformation and pediatric otosclerosis.<\/jats:p>","DOI":"10.1177\/0145561320944639","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T10:46:37Z","timestamp":1597401997000},"page":"333S-336S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed-Onset NOG Gene-Related Syndromic Conductive Deafness: A Case Report"],"prefix":"10.1177","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1530-1311","authenticated-orcid":false,"given":"Huiying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"},{"name":"Department of Otorhinolaryngology, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"bibr1-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21515"},{"key":"bibr2-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318211fada"},{"key":"bibr3-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1053\/hn.1999.v120.a89626"},{"key":"bibr4-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2011.01831.x"},{"key":"bibr5-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002393"},{"key":"bibr6-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.600607.x"},{"key":"bibr7-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000511784.21936.1b"},{"key":"bibr8-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819900489"},{"key":"bibr9-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2014.97"},{"key":"bibr10-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31105-8"},{"key":"bibr11-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25368"},{"key":"bibr12-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1038\/361547a0"},{"key":"bibr13-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1038\/nature01245"},{"key":"bibr14-0145561320944639","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00353"},{"key":"bibr15-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1086\/519697"},{"key":"bibr16-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310691200"},{"key":"bibr17-0145561320944639","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.04.015"}],"container-title":["Ear, Nose &amp; 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