{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:04:17Z","timestamp":1777561457297,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"MedicalHealth Science and Technology Project of ZhejiangProvincial Health Commission Grant","award":["OO20190775"],"award-info":[{"award-number":["OO20190775"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To develop and validate a clinical score to predict the risk of tympanosclerosis before surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A sample of 404 patients who underwent middle ear microsurgery for otitis media was enrolled. These patients were randomly divided into 2 cohorts: the training cohort (n = 243, 60%) and the validation cohort (n = 161, 40%). The preoperative predictors of tympanosclerosis were determined by multivariate logistic regression analysis and implemented using a clinical score tool. The predictive accuracy and discriminative ability of the clinical score were determined by the area under the curve (AUC) and the calibration curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The multivariate analysis in the training cohort (n = 243, 60%) identified independent factors for tympanosclerosis as the female sex (odds ratio [OR]: 3.83; 95% CI: 1.66-9.37), the frequency-specific air-bone gap at 250 Hz \u2265 45 dB HL (OR: 3.68; 95% CI: 1.68-8.57), aditus ad antrum blockage (OR: 3.29; 95% CI: 1.38-8.43), type I eardrum calcification (OR: 25.37; 95% CI: 8.41-88.91) or type II eardrum calcification (OR: 18.86; 95% CI: 6.89-58.77), and a history of otitis media \u2265 10 years (OR: 4.10; 95% CI: 1.58-11.83), which were all included in the clinical score tool. The AUC of the clinical score for predicting tympanosclerosis was 0.89 (95% CI: 0.85-0.93) in the training cohort and 0.89 (95% CI: 0.84-0.95) in the validation cohort. The calibration curve also showed good agreement between the predicted and observed probability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The clinical score achieved an optimal prediction of tympanosclerosis before surgery. The presence of calcification pearls on the promontorium tympani is a strong predictor of tympanosclerosis with stapes fixation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0145561320951676","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T15:26:10Z","timestamp":1599492370000},"page":"NP169-NP177","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and Validation of a Clinical Score for Predicting the Risk of Tympanosclerosis Before Surgery"],"prefix":"10.1177","volume":"101","author":[{"given":"Zhihuai","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaofei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-6251","authenticated-orcid":false,"given":"Mang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"bibr1-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215119002226"},{"key":"bibr2-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1007\/BF03050766"},{"key":"bibr3-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310900305"},{"key":"bibr4-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175993"},{"key":"bibr5-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.122701"},{"key":"bibr6-0145561320951676","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903193429"},{"key":"bibr7-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002152"},{"key":"bibr8-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1007\/BF00171431"},{"key":"bibr9-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1007\/s40136-020-00261-2"},{"key":"bibr10-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12389"},{"key":"bibr11-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100074879"},{"key":"bibr12-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001639"},{"key":"bibr13-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.11.015"},{"issue":"2","key":"bibr14-0145561320951676","first-page":"196","volume":"87","author":"Gibb AG","year":"1973","journal-title":"J Laryngol Otology"},{"key":"bibr15-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1097\/01.HJ.0000410386.88647.89"},{"key":"bibr16-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109005520"},{"key":"bibr17-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200209000-00025"},{"key":"bibr18-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0511-x"},{"key":"bibr19-0145561320951676","doi-asserted-by":"publisher","DOI":"10.3109\/01913123.2013.833563"},{"key":"bibr20-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1993.tb00590.x"},{"key":"bibr21-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-16399-0_18"},{"key":"bibr22-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114002345"},{"key":"bibr23-0145561320951676","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1099-0"}],"container-title":["Ear, Nose &amp; 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