{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:13:38Z","timestamp":1777562018616,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The role of autoimmune diseases on the risk for acute epiglottitis remains uncertain. This study aimed to delineate the association between epiglottitis and autoimmune diseases using population database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A population-based retrospective study was conducted to analyze claims data from Taiwan National Health Insurance Research Database collected over January, 2000, to December, 2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 2339 patients with epiglottitis were matched with 9356 controls without epiglottitis by sex, age, socioeconomic status, and urbanization level. The correlation between autoimmune diseases and epiglottitis was analyzed by multivariate logistic regression. Compared with controls, patients with epiglottitis were much more likely to have preexisting Sj\u00f6gren syndrome (adjusted odds ratio [aOR]: 2.37; 95% CI: 1.14-4.91;\n                      <jats:italic>P<\/jats:italic>\n                      = .021). In addition, polyautoimmunity was associated with increased risk of epiglottitis (aOR: 2.08; 95% CI: 1.14-3.80;\n                      <jats:italic>P<\/jats:italic>\n                      = .018), particularly in those aged &gt;50 years (aOR: 2.61; 95% CI: 1.21-5.66;\n                      <jats:italic>P<\/jats:italic>\n                      = .015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Among autoimmune diseases, we verify the association between epiglottitis and Sj\u00f6gren syndrome in Taiwan. Furthermore, we present the novel discovery that patients with epiglottitis have an increased risk of polyautoimmunity, particularly those aged &gt;50 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613211033689","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T15:05:33Z","timestamp":1627657533000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epiglottitis in Patients With Preexisting Autoimmune Diseases: A Nationwide Case\u2013Control Study in Taiwan"],"prefix":"10.1177","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-3784","authenticated-orcid":false,"given":"Cheng-Ming","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-5940","authenticated-orcid":false,"given":"Ming-Shao","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Hsu","family":"Yang","sequence":"additional","affiliation":[{"name":"Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi"},{"name":"Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko-Ming","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-4351","authenticated-orcid":false,"given":"Yun-Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-3360","authenticated-orcid":false,"given":"Meng-Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2789-189X","authenticated-orcid":false,"given":"Ethan I.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-9747","authenticated-orcid":false,"given":"Geng-He","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Yen","family":"Liu","sequence":"additional","affiliation":[{"name":"Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-0890","authenticated-orcid":false,"given":"Yao-Te","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199036"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22147"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.6.1640"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2007.050153"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy038"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.4.439"},{"issue":"2","key":"e_1_3_4_8_2","first-page":"332","article-title":"Hyposplenism in systemic lupus erythematosus","volume":"10","author":"Neilan BA","year":"1983","unstructured":"Neilan BA, Berney SN. 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