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Methods: Prospective, double-blinded, randomized study including 111 consecutive patients, between April 2012 and January 2017, afflicted by CRSwNP, CRSsNP, and CR. Patients from each group were randomly assigned to either PFE treatment or placebo twice daily for 30\u00a0days. Therapeutic efficacy was assessed by Ear Nose and Throat, blood and tomographic examinations, and the SNOT-20 questionnaire. Results: CR patients treated with PFE suffered significantly less from thick nasal discharge, difficulty falling asleep, reduced productivity, reduced concentration, and sadness ( P = .004, P = .02, P = .03, P = .007 and P = .02, respectively). Conclusions: Topical nasal PFE was found to have some benefits for CR patients, however, not for CRS with or without Nasal Polyposis.<\/jats:p>","DOI":"10.1177\/01455613211044224","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T06:20:27Z","timestamp":1632464427000},"page":"NP148-NP157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Chronic Rhinitis and Chronic Rhinosinusitis"],"prefix":"10.1177","volume":"103","author":[{"given":"Asaf","family":"Israeli","sequence":"first","affiliation":[{"name":"Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 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