{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:04:30Z","timestamp":1787018670232,"version":"build-2736575974"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>Objectives: To summarize the clinicopathological and genetic features of malignant paragangliomas in head and neck cancer and to explore the appropriate treatment options for this rare lesion. Methods: Six patients harboring head and neck malignant paraganglioma from Beijing Tongren Hospital were retrospectively reviewed. The clinicopathological characteristics, gene mutations, and prognosis of these patients were analyzed. Results: Of these 6 patients, 3 were male and 3 were female; 4 patients harbored malignant carotid body tumors, and two had malignant vagal paragangliomas. Three patients had cervical lymph node metastasis, two presented with lung and bone metastasis, and 1 had lung and liver metastasis. Of the 6 patients, four underwent surgical resection, and the other two patients denied surgery and instead received chemotherapy with paclitaxel, ifosfamide, and dacarbazine. These 2 patients with vagal paraganglioma received postoperative radiotherapy. All 6 patients are still alive at the present time, with a median follow-up time of 66\u00a0months. Positive Ki-67 expression in tumor tissue ranged from 1% to 40%. Genetic mutations in SDHD, SDHB, ATR, and MAP3K13 were identified in 4 patients. Conclusions: After comprehensive treatment, head and neck malignant paraganglioma can attain a favorable prognosis. Genetic mutations are commonly detected in patients with malignant paragangliomas. This study also identified mutations in ATR and MAP3K13 in these patients.<\/jats:p>","DOI":"10.1177\/01455613211052338","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T01:01:42Z","timestamp":1634346102000},"page":"298-304","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Head and Neck Malignant Paragangliomas: Experience from a Single Institution"],"prefix":"10.1177","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-3359","authenticated-orcid":false,"given":"Yiming","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0114-7608","authenticated-orcid":false,"given":"Lifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Otolaryngology of Qinghai Provincial People\u2019s Hospital, Xining, Qinghai Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"bibr1-01455613211052338","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)31720-5"},{"key":"bibr2-01455613211052338","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-001-0106-8"},{"key":"bibr3-01455613211052338","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5454.848"},{"key":"bibr4-01455613211052338","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"bibr5-01455613211052338","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199808)20:5<374::AID-HED3>3.0.CO;2-V"},{"key":"bibr6-01455613211052338","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10252"},{"key":"bibr7-01455613211052338","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23297"},{"key":"bibr8-01455613211052338","unstructured":"DeLellis RA, Lloyd RV, Heitz PU, et al, eds. 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