{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:15:53Z","timestamp":1789820153963,"version":"4.0.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>\n                    Objective: This study aims to explore the effects of laryngopharyngeal reflux disease (LPRD) and proton pump inhibitor (PPI) treatment on Eustachian tube function in patients with obstructive sleep apnea (OSA). Methods: The Eustachian tube score-7 (ETS-7) was observed before and after PPI treatment in the control group, OSA only group, and OSA + LPRD group. Results: Age, sex, smoking history, and drinking history showed no differences among 3 groups (P &gt; .05). The body mass index (BMI) in the control group was lower than that in other groups (P &lt; .017). Before PPI treatment, the abnormality rate of ETS-7 in the OSA + LPRD group statistically differed from that in the control group and the OSA only group (P &lt; .017). After PPI treatment, the abnormality rate of ETS-7 in the OSA + LPRD group exhibited no significant differences compared with that in the control group and the OSA only group (P &gt; .017), and it declined remarkably compared with that before PPI treatment (75% vs 35%, \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    = 13.334, P = .001). Moreover, the multivariate analysis revealed that only LPRD had an independent correlation with the abnormality of ETS-7 (OR = 1.245, 95% CI: 1.759\u20136.861, P = .000). Conclusion: In view of its high incidence in OSA patients, LPRD may be a considerable factor for the high incidence of abnormality rate of ETS-7 in OSA patients, and PPI therapy is of significant value in improving Eustachian tube function in OSA patients with LPRD.\n                  <\/jats:p>","DOI":"10.1177\/01455613221076786","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T07:45:00Z","timestamp":1645429500000},"page":"248-254","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of effects of laryngopharyngeal reflux disease and proton pump inhibitor treatment on Eustachian tube function in patients with obstructive sleep apnea hypopnea"],"prefix":"10.1177","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-0677","authenticated-orcid":false,"given":"Suying","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Bejing Anzhen Hospital, Captal Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Bejing Anzhen Hospital, Captal Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Bejing Anzhen Hospital, Captal Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"bibr1-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2019.12.004"},{"issue":"04","key":"bibr2-01455613221076786","first-page":"351","volume":"35","author":"Peng Y","year":"2021","journal-title":"J Otolaryngol-Head N"},{"key":"bibr3-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.07.002"},{"key":"bibr4-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.102993"},{"key":"bibr5-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2017.1385846"},{"key":"bibr6-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003123"},{"key":"bibr7-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2018.03.007"},{"key":"bibr8-01455613221076786","volume-title":"The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications","author":"Berry RB","year":"2016"},{"issue":"5","key":"bibr9-01455613221076786","first-page":"327","volume":"51","author":"Li J","year":"2016","journal-title":"Zhonghua er bi yan hou tou jing wai ke za zhi"},{"key":"bibr10-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24922"},{"issue":"14","key":"bibr11-01455613221076786","first-page":"1171","volume":"30","author":"Chen B","year":"2016","journal-title":"J Otolaryngol-Head N"},{"key":"bibr12-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-019-0723-6"},{"key":"bibr13-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01920.x"},{"key":"bibr14-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.09.006"},{"key":"bibr15-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815621557"},{"issue":"6","key":"bibr16-01455613221076786","first-page":"00046","volume":"2","author":"Young Kim H","year":"2015","journal-title":"J Otolaryngol ENT Res"},{"key":"bibr17-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7460891"},{"key":"bibr18-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-3178-2"},{"key":"bibr19-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000163746.81766.45"},{"key":"bibr20-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1709987"},{"key":"bibr21-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414526689"},{"key":"bibr22-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819827488"},{"key":"bibr23-01455613221076786","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16112056"},{"key":"bibr24-01455613221076786","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29676"}],"container-title":["Ear, Nose &amp; 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