{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:32:10Z","timestamp":1793975530075,"version":"4.8.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Health-related quality of life (QoL) is a measure that allows us to know the patient\u2019s perception of well-being and how it is affected by their disease and treatments. In cancer patients, sarcopenia has been associated with low scores on various instruments used to assess the QoL; however, little information is available on the effects of sarcopenia and sarcopenic obesity on the QoL of patients with head and neck cancer (H&amp;NC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study with 71 H&amp;NC patients aged between 40 and 80 years, we describe the scores on the instruments EORTC QLQ C-30 and EORTC QLQ-H&amp;N35 according to the sarcopenia phenotype (NSG, nonsarcopenic group; SG, sarcopenic group; and SOG, sarcopenic obesity group), hand-grip strength, gait speed, total lymphocyte count, albumin, cholesterol and C-reactive protein, and the relationships between these variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of sarcopenia and sarcopenic obesity was 48% and 28%, respectively. The QoL analysis showed that NSG had higher scores on the physical functioning scale [NSG 93 (83\u2013100); SG 73 (52\u201388); SOG 83 (53\u201393), P = .009] and lower scores on the fatigue scale [NSG 11 (0\u201322); S 39 (30\u201367); SOG 44 (14\u201356); P = .004]. The NSG had a higher hand-grip strength (31.1\u00a0kg) than SG (24.1\u00a0kg, P = .007) and SOG (26.3\u00a0kg, P = .001), and a lower C-reactive protein. The SG and SOG showed no differences between them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with sarcopenia or sarcopenic obesity have lower physical performance and a higher level of fatigue than nonsarcopenic patients. This loss of function can maintain or worsen sarcopenia due to the patient\u2019s self-restraint in physical exertion that encourages an increase in muscle tissue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613221076791","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T13:26:11Z","timestamp":1646054771000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Quality of Life and Functionality of Head and Neck Cancer Patients Are Diminished As a Function of Sarcopenia and Obesity"],"prefix":"10.1177","volume":"104","author":[{"given":"Brenda-Eugenia","family":"Mart\u00ednez-Herrera","sequence":"first","affiliation":[{"name":"Instituto Mexicano del Seguro Social"},{"name":"Instituto Mexicano del Seguro Social"},{"name":"Universidad de Colima"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjam\u00edn","family":"Trujillo-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidad de Colima"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-6962","authenticated-orcid":false,"given":"Daniel","family":"Sat-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social"},{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faviola","family":"Gonz\u00e1lez-Barba","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"},{"name":"Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social"},{"name":"Universidad de Colima"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Cruz-corona","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis H\u00e9ctor","family":"Bayardo-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Sol\u00f3rzano-Mel\u00e9ndez","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David-Abdiel","family":"O\u00f1ate-Zubdia","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4293-5360","authenticated-orcid":false,"given":"Ruben-Eduardo","family":"Mor\u00e1n-Galav\u00edz","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Daniel","family":"Flores-Carlos","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"D\u00e1valos-Cobi\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Salazar-P\u00e1ramo","sequence":"additional","affiliation":[{"name":"Universidad de Guadalajara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulfo-Hern\u00e1n","family":"Nava-Zavala","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"},{"name":"Instituto Mexicano del Seguro Social"},{"name":"Universidad Aut\u00f3noma de Guadalajara"},{"name":"Hospital General de Occidente"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-7040","authenticated-orcid":false,"given":"Eduardo","family":"G\u00f3mez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara"},{"name":"Universidad de Guadalajara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-457X","authenticated-orcid":false,"given":"Luz-Ma-Adriana","family":"Balderas-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"},{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"International Agency for Research on Cancer. 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