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These patients present with throat pain, cystic\/necrotic lymphadenopathy, and mucosal swelling. Sometimes this constellation of symptoms can be mistaken for head and neck cancer. We report a case of an enlarging throat and painless cystic neck mass in a transgender woman in her forties who was initially suspected to have oropharyngeal squamous cell carcinoma. A subsequent workup revealed the presence of spirochetes without cellular atypia consistent with secondary syphilis. We include the ultrasonography images as well as an endoscopic photograph of the oropharyngeal manifestation in this report.<\/jats:p>","DOI":"10.1177\/01455613221095605","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T23:25:26Z","timestamp":1655421926000},"page":"218-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Secondary syphilis of the oropharynx and cervical lymph nodes: a case report"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4427-6634","authenticated-orcid":false,"given":"Albert Y","family":"Han","sequence":"first","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer N","family":"Wang","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice C","family":"Yu","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis L","family":"Shiba","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2015.990384"},{"key":"e_1_3_3_3_2","volume-title":"(Men Who Have Sex With Men) - CDC Fact Sheet","author":"CDC. 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