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He presented a history of a slow-growing painless mass in the lower part of his right jaw. Ultrasonography showed a swollen lymph node in the vicinity of the right submandibular gland. Contrast-enhanced computed tomography revealed a heterogeneous, low-contrast mass on the right of the neck. Magnetic resonance imaging revealed a heterogeneously enhanced mass in gadolinium-enhanced T1-weighted images. The fine needle biopsy showed spindle-shaped cells and HS was suspected. Fluorodeoxyglucose positron emission tomography revealed uptake by the tumor alone. The patient underwent right upper neck dissection and resection of the submandibular salivary glands. No postoperative adjuvant treatment was administered, but 2-year survival was achieved. Histopathological examination showed proliferation of large, pleomorphic atypical cells without differentiation into lymphocytes, which proved their differentiation into histiocytes. A bone marrow biopsy showed no evidence of monocytic leukemia. Thus, a diagnosis of HS was made. With local treatment alone, our patient achieved long-term survival, maintaining his quality of life.<\/jats:p>","DOI":"10.1177\/01455613221097200","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T10:47:31Z","timestamp":1650451651000},"page":"NP54-NP58","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A case of primary histiocytic sarcoma arising from a neck lymph node"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-608X","authenticated-orcid":false,"given":"Akinobu","family":"Kubota","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Japanese Red Cross Kitami Hospital, Kitami, Japan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Japanese Red Cross Kitami Hospital, Kitami, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Japanese Red Cross Kitami Hospital, Kitami, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Japanese Red Cross Kitami Hospital, Kitami, Japan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Japanese Red Cross Kitami Hospital, Kitami, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-8044","authenticated-orcid":false,"given":"Nobuyuki","family":"Bandoh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asahikawa Kosei Hospital, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asahikawa Medical University, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroji","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Department of Pathology, Japanese Red Cross Kitami Hospital, Kitami, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Harabuchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"bibr1-01455613221097200","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.53.1"},{"key":"bibr2-01455613221097200","unstructured":"Swerdlow SH, Campo E, Harris NL, et al., eds. 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