{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:24:54Z","timestamp":1777562694901,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Youth Science Foundation of China","doi-asserted-by":"crossref","award":["82002868"],"award-info":[{"award-number":["82002868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M673250"],"award-info":[{"award-number":["2020M673250"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2020SCU12049"],"award-info":[{"award-number":["2020SCU12049"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["GSALK2020021"],"award-info":[{"award-number":["GSALK2020021"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Science and Technology Department of Sichuan Province","award":["2020YFH0090"],"award-info":[{"award-number":["2020YFH0090"]}]},{"name":"The Science and Technology Department of Sichuan Province","award":["2020YFS0111"],"award-info":[{"award-number":["2020YFS0111"]}]},{"name":"The Science and Technology Department of Sichuan Province","award":["2022YFS0066"],"award-info":[{"award-number":["2022YFS0066"]}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","award":["2019-YF05-00461-SN"],"award-info":[{"award-number":["2019-YF05-00461-SN"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2019HXBH079"],"award-info":[{"award-number":["2019HXBH079"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2019HXFH003"],"award-info":[{"award-number":["2019HXFH003"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYJC21027"],"award-info":[{"award-number":["ZYJC21027"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Foundation of National Clinical Research Center for Geriatrics","award":["Z20201013"],"award-info":[{"award-number":["Z20201013"]}]},{"name":"The Health Department of Sichuan Province","award":["20PJ030"],"award-info":[{"award-number":["20PJ030"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>More patients with oropharyngeal squamous cell carcinoma (OPSCC) in Eastern countries receive surgically inclusive treatment (SIT), while most patients in Western countries receive nonsurgical treatment (NST). The optimal treatment modality for OPSCC patients remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 153 consecutive OPSCC cases diagnosed between 2009 and 2019 in West China Hospital (WCH) and 15,400 OPSCC cases from the Surveillance, Epidemiology, and End Results (SEER) database (2000\u20132017) were obtained. Clinical characteristics, treatments, and survival outcomes were retrospectively collected. We constructed Kaplan\u2013Meier curves and performed univariate (UVA) and multivariate (MVA) analyses to compare the prognosis of OPSCC patients among the WCH, SEER Asian, and SEER all ethnic populations by different treatment modality, human papilloma virus (HPV) infection status, age, and tumor stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, the proportions of patients with younger age, advanced tumors and HPV-negative status, and receiving SIT in WCH population were higher than those in the SEER all ethnic population, while the proportions in the SEER Asian population were between those of the other two populations. We observed consistent beneficial effects of SIT on the overall survival (OS) in OPSCC patients in all three populations (SEER Asian: MVA, hazard ratio (HR): 0.2,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001; SEER all ethnic: MVA, HR: 0.46,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001; WCH: UVA, HR: 0.62,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .071), and HPV-negative Asian patients showed greater benefits from the SIT than HPV-positive Asian patients (HPV Negative: HR: 0.16,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .005; HPV positive: HR = 0.28,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .059). Male was a risk factor for reduced OS in OPSCC patients in the WCH population (HR: 3.17, p = .043), but was a protective factor in the SEER population (HR: 0.8,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .002), which might be related to the differences of HPV infection status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Even though differences in patient characteristics existed between the Chinese, American, and Asian American populations, our ten-year real-world data and SEER data suggested that patients with OPSCC who received SIT had a better prognosis than those who received NST.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613221115608","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T17:08:27Z","timestamp":1657904907000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Survival Outcomes Related to Treatment Modalities in Patients With Oropharyngeal Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0368-6258","authenticated-orcid":false,"given":"Danni","family":"Cheng","sequence":"first","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufang","family":"Rao","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqing","family":"Qiu","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre and Dalla Lana School of Public Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Song","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendu","family":"Pang","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Qiu","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Dong","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiurui","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Sichuan University"},{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre and Dalla Lana School of Public Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Ren","sequence":"additional","affiliation":[{"name":"Sichuan University"},{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0227-z"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S271735"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32164"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.10.005"},{"key":"e_1_3_4_7_2","first-page":"57","article-title":"HPV integration in head and neck squamous cell carcinomas: Cause and consequence. recent results in cancer research","volume":"206","author":"Speel EJM","year":"2017","unstructured":"Speel EJM. 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