{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:26:34Z","timestamp":1777562794064,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutaneous malignant melanoma (CMM) is one of the most aggressive skin tumors. Sentinel lymph node biopsy (SLNB) is an important test before thorough treatment of melanoma. The aim of this study was to investigate cancer-specific survival (CSS) in patients with head and neck CMM after negative SLNB and to analyze predictors of decreased survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on the Surveillance, Epidemiology and End Results (SEER) database, a study was conducted using data from patients with head and neck CMM after negative SLNB. The demographic, clinical, and pathological characteristics of the case population were analyzed. Cox univariate, Kaplan\u2013Meier analysis, and multivariate Cox regression models were used to explore predictors of decreased survival; propensity score matching (PSM) analysis was used to reduce confounding bias, and outcomes were compared between the wide margin excision and narrow margin excision groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1597 confirmed head and neck CMM patients with SLNB-negative were found. A Breslow&gt;4.0\u00a0mm was the highest independent risk predictor for patients (HR 3.82, 95% CI 2.04-7.16,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and significant risk independent predictors also included a high mitotic rate &gt;4 (HR 1.54, 95% CI 1.06-2.25,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .023). Age&lt; 60\u00a0years old was a significant survival predictor (HR 0.56, 95% CI .37-.85,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .007), and not scalp and neck CMM were also important factors for longer survival (auricle skin: HR .51, 95% CI .29-.90,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02; unspecified parts of face: HR .59, 95% CI .40-.87,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .007). After harmonizing baseline data by PSM, it was found that the extent of surgical resection did not affect patient survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study analyzed the risk factors affecting CSS in patients with CMM of the head and neck region with SLNB-negative and observed a statistically significant difference in the prognosis of patients with CMM in different aesthetic subunits of the head and neck region. Close clinical follow-up for this population is necessary, and periodic medical examinations should be carried out.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613221126327","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T01:04:36Z","timestamp":1663549476000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Survival analysis in head and neck melanoma after negative sentinel lymph node biopsy: A seer-based population study"],"prefix":"10.1177","volume":"104","author":[{"given":"Shulian","family":"Li","sequence":"first","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanlan","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juxiang","family":"Gou","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"You","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-8654","authenticated-orcid":false,"given":"Qiang","family":"Ji","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13024"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-021-10123-w"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26565"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-014-1221-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.01.007"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3048"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.605"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-07099-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2014.07.011"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29767"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4912-6"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3954-5"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20197414"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000458530"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06901-7"},{"issue":"6","key":"e_1_3_3_18_2","first-page":"1083","article-title":"Patient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival","volume":"7","author":"Tas F","year":"2017","unstructured":"Tas F, Erturk K. Patient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival. Mol Clin Oncol. 2017;7(6):1083-1088.","journal-title":"Mol Clin Oncol"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-09929-5"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.09.003"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.5032"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyab022"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25153"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2021.06.003"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613221126327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613221126327","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613221126327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:37:26Z","timestamp":1777401446000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613221126327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,18]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/01455613221126327"],"URL":"https:\/\/doi.org\/10.1177\/01455613221126327","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,18]]}}}