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Modern management of complicated RRP should include both local debulking and systemic approaches. Systemic bevacizumab (Avastin) has shown some initial success as an effective treatment option, in addition to other medications such as pembrolizumab. Other future care strategies may include an HPV vaccination and other adjuvants; vaccination has been reported to have the possibility of drastically reducing the incidence of RRP.<\/jats:p>","DOI":"10.1177\/01455613221128714","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T06:29:02Z","timestamp":1664432942000},"page":"47S-51S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Laryngotracheal Recurrent Papillomatosis: A Case Study and Survey of Surgical and Systemic Management"],"prefix":"10.1177","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1311-9329","authenticated-orcid":false,"given":"Michela","family":"Borrelli","sequence":"first","affiliation":[{"name":"Cedars Sinai Sinus Center of Excellence, Los Angeles, CA, USA"},{"name":"Cedars-Sinai Division of Otolaryngology, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasha","family":"Nasrollahi","sequence":"additional","affiliation":[{"name":"Cedars Sinai Sinus Center of Excellence, Los Angeles, CA, USA"},{"name":"Cedars-Sinai Division of Otolaryngology, Los Angeles, CA, USA"},{"name":"California Northstate University College of Medicine, Elk Grove, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5961-4344","authenticated-orcid":false,"given":"Jonathan","family":"Raskin","sequence":"additional","affiliation":[{"name":"Cedars Sinai Sinus Center of Excellence, Los Angeles, CA, USA"},{"name":"Cedars-Sinai Division of Otolaryngology, Los Angeles, CA, USA"},{"name":"Oakland University William Beaumont School of Medicine, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Khan","sequence":"additional","affiliation":[{"name":"American University of Antigua College of Medicine, Osbourn, AN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronda E","family":"Alexander","sequence":"additional","affiliation":[{"name":"Cedars Sinai Sinus Center of Excellence, Los Angeles, CA, USA"},{"name":"Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"bibr1-01455613221128714","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29084"},{"key":"bibr2-01455613221128714","unstructured":"Ruiz R, Balamuth N, Javia LR, Zur KB. 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