{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:00:35Z","timestamp":1777561235778,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","award":["006629-00001"],"award-info":[{"award-number":["006629-00001"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Importance:<\/jats:title>\n                    <jats:p>Operative laryngoscopy is a commonly performed ambulatory procedure in patients with significant co-morbidity. Optimal anesthetics for surgical exposure with rapid return to baseline after the procedure enhances postoperative patient safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether sugammadex hastens recovery in patients undergoing operative laryngoscopy under general anesthesia with rocuronium-induced paralysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Prospective clinical intervention randomized single-blinded, single-center study in an academic tertiary care center. Approved by the institutional review board and registered with\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings<\/jats:title>\n                    <jats:p>Single center tertiary care academic institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>18\u00a0years or older, American Society of Anesthesiology physical status I\u2013III with ability to give written informed consent undergoing operative laryngoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Participants were randomized into two groups. Both groups received inhaled anesthetic: sevoflurane, remifentanil, and rocuronium at 0.6\u20131.2 mg\/kg for intubation and anti-nausea prophylaxis. Group 1 received reversal with neostigmine (0.04 mg\/kg) and glycopyrrolate (0.01 mg\/kg). Group 2 received reversal with sugammadex (4 mg\/kg). Vital signs were maintained at 20% of baseline in both groups. Post anesthesia care unit nurses were blinded to the reversal agent and were the evaluators of the discharge criteria and times. Primary end point was time to extubation after the procedures and secondary end points were: Subjective interpretation of surgical conditions by the surgeon, hemodynamic, respiratory parameters, anesthetics, and opioids used, operative time, and duration to achieve discharge readiness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of eighty-four participants, who were similar in age, sex, and weight in both groups. The primary end point and secondary end points were similar except time to meet discharge criteria in the two groups. 65% in the sugammadex versus 35% in the neostigmine group met Aldrete criteria of 18 or higher on arrival at the post anesthesia care unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Optimizing the anesthetic regimen, along with stable intraoperative hemodynamics and reversal with sugammadex improves discharge readiness in patients undergoing operative laryngoscopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613221132391","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T02:18:48Z","timestamp":1672712328000},"page":"576-581","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Optimizing Reversal of Muscle Relaxation with Sugammadex to Accelerate Discharge Readiness in Operative Laryngoscopy: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8098-1045","authenticated-orcid":false,"given":"Pavithra R","family":"Ellison","sequence":"first","affiliation":[{"name":"Medical Center Drive, Morgantown, WV, USA"},{"name":"Department of Anesthesiology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alec","family":"Statler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Dragan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Mc","family":"Chesney","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffson","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Fancy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle M","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew B","family":"Ellison","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-1720-4.00425-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2196\/13156"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27956"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24199"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710601010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-016-0221-2"},{"key":"e_1_3_3_8_2","unstructured":"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2004\/20630se5-005_ultiva_lbl.pdf"},{"issue":"3","key":"e_1_3_3_9_2","first-page":"508","article-title":"Discharge criteria and complications after ambulatory surgery","volume":"88","author":"Marshall SI","year":"1999","unstructured":"Marshall SI, Chung F. Discharge criteria and complications after ambulatory surgery. Anesth Analg. 1999;88(3):508-517.","journal-title":"Anesth Analg"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2012.06.009"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.8931"},{"key":"e_1_3_3_12_2","unstructured":"Pandharipande PP Whitlock EL Hughes CG. Baseline Vulnerabilities May Play a Larger Role than Depth of Anesthesia or Sedation in Postoperative."},{"key":"e_1_3_3_13_2","unstructured":"https:\/\/www.merck.com\/product\/usa\/pi_circulars\/b\/bridion\/bridion_pi.pdf."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq269"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta14390"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq270"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S109951"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew246"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613221132391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613221132391","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613221132391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:33:07Z","timestamp":1777401187000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613221132391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,2]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/01455613221132391"],"URL":"https:\/\/doi.org\/10.1177\/01455613221132391","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,2]]}}}