{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:01:11Z","timestamp":1777561271323,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    Nocardia is regarded as an opportunistic pathogen primarily affecting the respiratory system, whereas\n                    <jats:italic toggle=\"yes\">Nocardia farcinica<\/jats:italic>\n                    is the species of the Nocardia family that is most frequently blamed for central nervous system impairment. The authors present the first case of mastoiditis caused by\n                    <jats:italic toggle=\"yes\">Nocardia farcinica<\/jats:italic>\n                    , accompanied by intracranial complications. An immunocompetent 74-year-old woman who reported a three-week left ear discharge and a two-week facial nerve palsy was referred to our department. MRI revealed mastoiditis and epidural abscess. The bacterial cultures obtained during the surgical management of the patient confirmed the presence of\n                    <jats:italic toggle=\"yes\">Nocardia farcinica<\/jats:italic>\n                    . Targeted antibiotic therapy was subsequently administrated, gradually resulting in favourable outcomes. Nocardia species provoke a disseminated infection that emerges not only among the immunosuppressed individuals but can also affect the healthy population. The nonspecific clinical manifestations in addition to the difficulties identifying the pathogen, remain obstacles to a punctual diagnosis. However, the combination of surgical debridement and antibiotic treatment with trimethoprim and sulfamethoxazole is considered the most appropriate management, leading to propitious results.\n                  <\/jats:p>","DOI":"10.1177\/01455613221139400","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T08:34:23Z","timestamp":1669883663000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Nocardia Farcinica Mastoiditis and Epidural Abscess in an Immunocompetent Patient: A Rare Entity"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-3518","authenticated-orcid":false,"given":"Eleni","family":"Gkrinia","sequence":"first","affiliation":[{"name":"Tampere University"},{"name":"University of Thessaly"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argyro","family":"Bizaki-Vallaskangas","sequence":"additional","affiliation":[{"name":"Tampere University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Rautiainen","sequence":"additional","affiliation":[{"name":"Tampere University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Kivek\u00e4s","sequence":"additional","affiliation":[{"name":"Tampere University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.11.012"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.590239"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.04.022"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2021.04.022"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.07.033"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-021-00562-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(86)90015-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1258\/0049475053001903"},{"issue":"5","key":"e_1_3_3_10_2","first-page":"688","article-title":"Nocardia infection of the mastoid in an immunocompromised patient","volume":"59","author":"Subha ST","year":"2004","unstructured":"Subha ST, Raman R. Nocardia infection of the mastoid in an immunocompromised patient. Medical Journal of Malaysia. 2004;59(5):688-689.","journal-title":"Medical Journal of Malaysia"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521644112"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2012.205"},{"issue":"4","key":"e_1_3_3_13_2","first-page":"314","article-title":"Otitis media aguda por Nocardia asteroides [Acute otitis media caused by Nocardia asteroides]","volume":"47","author":"Salvo Gonzalo S","year":"1996","unstructured":"Salvo Gonzalo S, Grijalba Uche M, Maz\u00f3n Ramos A, Vila Mendiburu I. Otitis media aguda por Nocardia asteroides [Acute otitis media caused by Nocardia asteroides]. 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