{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:02:21Z","timestamp":1777561341825,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the clinical diagnosis and treatment characteristics of primary laryngeal neuroendocrine carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed for the data of 6 patients with primary laryngeal neuroendocrine carcinoma admitted to the Department of Otorhinolaryngology of Dalian Central Hospital from September 2015 to January 2022, all of whom were male patients. And laryngoscopy showed that 4 had a similar appearance to hemangioma, 1 had nodular hyperplasia, and 1 was papilloma-like. The site of onset was located on the laryngeal surface of the epiglottis in 3 cases, situated in the aryepiglottic fold in 2 cases, and the posterior ventricular zone in 1 case. Five patients underwent surgery, including 4 by transoral endoscopic cryogenic plasma radiofrequency mass resection; one underwent a cervical lymph node dissection and supraglottic horizontal hemilaryngectomy. The remaining 1 case was treated in another hospital after the pathological diagnosis was confirmed by biopsy. All patients had no cervical lymph node metastases and were not supplemented with chemoradiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The postoperative pathological diagnosis of all 5 patients was neuroendocrine carcinoma. No cancer cells were seen at the margins and base. One patient was lost to follow-up after treatment in another hospitals and the rest were followed up for 6\u00a0months to 6\u00a0years. One patient had removed laryngeal tumor and epiglottis by a low-temperature plasma radiofrequency ablation, recurrence 1\u00a0year after surgery, and no recurrence for 5\u00a0years after supraglottic horizontal hemilaryngectomy combined with prophylactic cervical lymph node dissection, no recurrence for the other 4\u00a0patients after 6\u00a0months to 4\u00a0years of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The common sites of laryngeal neuroendocrine carcinoma are the laryngeal surface of the epiglottis and the aryepiglottic fold. The appearance of the tumor is mainly similar to that of hemangioma. Moreover, a common pathological classification is atypical carcinoid tumors, where early detection and surgical treatment can achieve a good therapeutic effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613231155853","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T20:24:31Z","timestamp":1675455871000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Diagnosis and Treatment of Primary Laryngeal Neuroendocrine Carcinoma"],"prefix":"10.1177","volume":"104","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Dalian municipal Central Hospital, Dalian, China"},{"name":"Graduate School of Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Dalian municipal Central Hospital, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-8925","authenticated-orcid":false,"given":"Cuiping","family":"She","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Dalian municipal Central Hospital, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30400"},{"key":"e_1_3_5_3_2","first-page":"145561321102486","article-title":"Atypical carcinoid of the larynx: a case report","author":"Hu Y","year":"2021","unstructured":"Hu Y, Guo X, Jiang F, Yan A. Atypical carcinoid of the larynx: a case report [published online ahead of print, 2021 Jul 5]. Ear Nose Throat J. 2021:1455613211024868.","journal-title":"Ear Nose Throat J"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0894-6"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqz106"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00397"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29554"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320952191"},{"key":"e_1_3_5_9_2","first-page":"145561321106244","article-title":"Clinical application of low-temperature plasma radiofrequency in the treatment of hemangioma in nasal cavity, pharynx and larynx","author":"Long X","year":"2021","unstructured":"Long X, Li Z, Liu Y, Zhen H. Clinical application of low-temperature plasma radiofrequency in the treatment of hemangioma in nasal cavity, pharynx and larynx [published online ahead of print, 2021 Dec 10]. Ear Nose Throat J. 2021:1455613211062443.","journal-title":"Ear Nose Throat J"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29703"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01367-9"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23666"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215118000968"},{"issue":"8","key":"e_1_3_5_14_2","first-page":"e1558","article-title":"Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report","volume":"5","author":"Fiorini FR","year":"2022","unstructured":"Fiorini FR, Abbas Y, Mukhopadhyay S, Tatla T. Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report. Cancer Rep (Hoboken). 2022;5(8):e1558.","journal-title":"Cancer Rep (Hoboken)"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211014784"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-019-00933-6"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613231155853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613231155853","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613231155853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:33:27Z","timestamp":1777401207000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613231155853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/01455613231155853"],"URL":"https:\/\/doi.org\/10.1177\/01455613231155853","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,3]]}}}