{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:03:48Z","timestamp":1777561428894,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Subject Construction Project of Pu dong Health Committee of Shanghai","award":["PWZy2020-06"],"award-info":[{"award-number":["PWZy2020-06"]}]},{"name":"Research Grant for Health Science and Technology of Pudong Health Bureau of Shanghai","award":["PW2019D-4"],"award-info":[{"award-number":["PW2019D-4"]}]},{"name":"key Specialty Construction Project of Health Bureau of Shanghai","award":["ZK2019C06"],"award-info":[{"award-number":["ZK2019C06"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Spindle epithelial tumor with thymus-like differentiation of thyroid (SETTLE) is very rare neoplasm with 2 cellular forms, epithelial cell and spindle cell, and most reported cases have been in young people. An 11-year-old boy presented with painless swelling of the right neck lasting for more than 2\u00a0months. A tumor size measuring approximately 3 \u00d7 3\u00a0cm was resected, and intraoperative frozen pathology suggested a spindle cell tumor, which was confirmed as SETTLE by immunohistochemical staining and external hospital consultation. The immunohistochemical staining profile of the resected tumor tissue was as follows: cytokeratin (CK) (+), smooth muscle actin (weak+), vimentin (+), CK7 (focal+), B-cell lymphoma 2 (partial+), CD99 (\u2212), calcitonin (+), galectin-3 (+), CK19 (+), and Ki-67 (10%+). Ultrasound at 1-year postoperative follow-up revealed no local recurrence of the lesion or lymph node metastasis in the thyroid gland. We summarized the disease characteristics of SETTLE among 6 cases reported to date and found that SETTLE is associated with a good prognosis and low postoperative recurrence rate. Thus, for this type of malignant thyroid tumor, diagnosis depends mainly on postoperative pathology and immunohistochemical staining and simple surgical resection is recommended.<\/jats:p>","DOI":"10.1177\/01455613231171826","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T17:43:37Z","timestamp":1685382217000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Spindle Epithelial Tumor With Thymus-Like Differentiation of Thyroid (SETTLE): A Case Report and Literature Review"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-9826","authenticated-orcid":false,"given":"Dan","family":"Lu","sequence":"first","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2643-0685","authenticated-orcid":false,"given":"Runyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8252-7778","authenticated-orcid":false,"given":"Enhui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocheng","family":"Xue","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Li","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuixian","family":"Huang","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-020-09638-x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01656263"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90083-2"},{"issue":"11","key":"e_1_3_4_5_2","first-page":"e31574","article-title":"Spindle epithelial tumor with thymus-like differentiation (settle) misdiagnosed as papillary thyroid carcinoma: A case report","volume":"14","author":"Kathamuthu K","year":"2022","unstructured":"Kathamuthu K, Janardan C, Ramkumar S, et al. Spindle epithelial tumor with thymus-like differentiation (settle) misdiagnosed as papillary thyroid carcinoma: A case report. 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