{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:04:20Z","timestamp":1777561460190,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    A 72-year-old Japanese man with a 4-month history of hoarseness and 1-week history of difficulty breathing was admitted to our department. He underwent right total nephrectomy for primary clear cell-type renal cell carcinoma (RCC) 6\u2009years ago and left partial nephrectomy for the metastasis 4\u2009years ago. Flexible laryngeal fiberscope examination revealed bilateral subglottic stenosis without obvious mucosal lesions. Enhanced computerized tomography (CT) scan of the neck revealed that the cricoid cartilage had become bilaterally expansive and tumorous lesion exhibiting enhancement. We performed tracheostomy on the appointed day and biopsied the tumor in the cricoid cartilage via the skin incision. Results of histologic and immunohistologic examinations for AE1\/AE3, CD10, and vimentin positivity were consistent with clear cell-type RCC. Chest and abdomen CT scans revealed a few tiny metastases in the upper lobe of the left lung but no recurrence in the abdomen. At 2\u2009weeks from the day of tracheostomy, total laryngectomy was performed. Postoperatively, the patient was treated transorally with axitinib (10\u2009mg\/day) and as of 12\u2009months he remains alive with unchanging lung metastasis. Next-generation sequencing of targeted regions using a surgical specimen from the tumor revealed a frameshift mutation in the von Hippel-Lindau gene (p.T124Hfs*35) and a missense mutation in the\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    gene (p.H193R).\n                  <\/jats:p>","DOI":"10.1177\/01455613231177188","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T03:08:44Z","timestamp":1685070524000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Renal Cell Carcinoma Metastasizing to the Cricoid Cartilage Presenting With Subglottic Stenosis: A Case Report and Literature Review"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-8044","authenticated-orcid":false,"given":"Nobuyuki","family":"Bandoh","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-608X","authenticated-orcid":false,"given":"Akinobu","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido, Japan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuhei","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido, Japan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Sakaue","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido, Japan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hokuto Hospital, Obihiro, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsumi","family":"Hashiba","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hokuto Hospital, Obihiro, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hokuto Hospital, Obihiro, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"issue":"5","key":"e_1_3_3_2_2","first-page":"489","article-title":"Clinicopathologic features of renal cell carcinoma in young adults: a comparison study with renal cell carcinoma in older patients","volume":"2","author":"Suh JH","year":"2009","unstructured":"Suh JH, Oak T, Ro JY, et al. Clinicopathologic features of renal cell carcinoma in young adults: a comparison study with renal cell carcinoma in older patients. Int J Clin Exp Pathol. 2009;2(5):489-493.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.06.037"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00184870"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2015.10.015"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr362"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198612000-00007"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197309000-00011"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199607000-00013"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100102841"},{"issue":"1","key":"e_1_3_3_11_2","first-page":"16","article-title":"Metastatic renal carcinoma to larynx","volume":"16","author":"Maung R","year":"1987","unstructured":"Maung R, Burke RC, Hwang WS. 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