{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:13:23Z","timestamp":1788786803824,"version":"build-2803163510"},"reference-count":10,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by hypercalcemia and elevated or abnormally normal parathyroid hormone (PTH) levels, due to excessive secretion of PTH by 1 or more parathyroid glands. In this report, we discuss the diagnostic and therapeutic challenges posed by ectopic parathyroid adenomas, a rare but atypical presentation of PHPT. We present the case of a 36-year-old female with PHPT due to an ectopic parathyroid adenoma located in the submandibular region. The patient presented with bone pain and was initially evaluated with routine imaging studies, which were negative. [18F] F-choline positron emission tomography (PET)\/Computed tomography revealed the ectopic adenoma, leading to successful surgical management. Ectopic parathyroid adenomas are rare but can occur in various locations, and functional imaging modalities such as choline PET can aid in their detection. Surgical resection remains the definitive treatment for parathyroid adenomas, with intraoperative PTH monitoring guiding the extent of resection. Proper evaluation and management of PHPT is essential to avoid significant morbidity. Our case adds to the growing body of literature on the importance of considering ectopic locations of parathyroid adenomas in patients with PHPT.<\/jats:p>","DOI":"10.1177\/01455613231177193","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T04:55:07Z","timestamp":1684904107000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Submandibular Ectopic Parathyroid Adenoma: A Case Report"],"prefix":"10.1177","volume":"104","author":[{"given":"Jose Antonio","family":"Hakim Tawil","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, Fundaci\u00f3n Santa Fe de Bogot\u00e1 University Hospital, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Fl\u00f3rez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Fundaci\u00f3n Santa Fe de Bogot\u00e1 University Hospital, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Camila","family":"Sanabria","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Fundaci\u00f3n Santa Fe de Bogot\u00e1 University Hospital, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Palau","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fundaci\u00f3n Santa Fe de Bogot\u00e1 University Hospital, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-6575","authenticated-orcid":false,"given":"Juan Jose","family":"Santiva\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Fundaci\u00f3n Santa Fe de Bogot\u00e1 University Hospital, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3716-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31430-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.10.005"},{"issue":"3","key":"e_1_3_2_5_2","first-page":"541","article-title":"The surgical management of hyperparathyroidism","volume":"29","author":"Norman J.","year":"2000","unstructured":"Norman J. The surgical management of hyperparathyroidism. Endocrinol Metab Clin North Am. 2000;29(3):541-558.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200205000-00008"},{"key":"e_1_3_2_7_2","volume-title":"StatPearls","author":"Adkisson CD","year":"2022","unstructured":"Adkisson CD, Sharma J. Ectopic parathyroid adenoma. In: StatPearls [Internet]. StatPearls Publishing; 2022."},{"issue":"2","key":"e_1_3_2_8_2","first-page":"145","article-title":"Parathyroid imaging: technique and role in the preoperative evaluation of primary hyperparathyroidism","volume":"67","author":"Patel CN","year":"2012","unstructured":"Patel CN, Salahudeen HM, Lansdown M, Scarsbrook A. Parathyroid imaging: technique and role in the preoperative evaluation of primary hyperparathyroidism. Clin Radiol. 2012;67(2):145-155.","journal-title":"Clin Radiol"},{"key":"e_1_3_2_9_2","volume-title":"Kumar and Clark\u2019s Clinical Medicine","author":"Kumar P","year":"2017","unstructured":"Kumar P, Clark M. Kumar and Clark\u2019s Clinical Medicine. 9th ed. Elsevier; 2017.","edition":"9"},{"issue":"10","key":"e_1_3_2_10_2","first-page":"e446","article-title":"Choline PET or PET\/CT and parathyroid glands: a systematic literature review","volume":"41","author":"Giovanella L","year":"2016","unstructured":"Giovanella L, Avram AM, Iakovou I. Choline PET or PET\/CT and parathyroid glands: a systematic literature review. Clin Nucl Med. 2016;41(10): e446-e452.","journal-title":"Clin Nucl Med"},{"issue":"11","key":"e_1_3_2_11_2","first-page":"958","article-title":"An unusual presentation of ectopic parathyroid adenoma: a case report and review of the literature","volume":"71","author":"Wachtel H","year":"2005","unstructured":"Wachtel H, Siperstein A, Wang C. An unusual presentation of ectopic parathyroid adenoma: a case report and review of the literature. 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