{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:04:55Z","timestamp":1777561495578,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970887"],"award-info":[{"award-number":["81970887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study aims to examine the clinical efficacy and prognostic factors associated with nerve growth factor (NGF) treatment for sudden sensorineural hearing loss (SSHL).\n                    <jats:bold>Materials and methods<\/jats:bold>\n                    : A retrospective analysis was conducted on the clinical data of 101 patients with moderate or more severe SSHL who underwent secondary treatment at Sun Yat-sen Memorial Hospital of Sun Yat-sen University between January 2019 and July 2020. Prior to treatment, all patients were assessed using Pure Tone Audiometry (PTA), auditory brainstem response, otoacoustic emission, temporal bone computed tomography, or inner ear magnetic resonance imaging. Fifty-seven patients received conventional systemic treatment and served as the control group, while 44 patients received NGF in conjunction with conventional systemic treatment, forming the experimental group. PTA results were compared between the two groups before treatment and at 1\u2009week, 2\u2009weeks, and 1\u2009month post-treatment. Additionally, the impact of age, sex, affected side, hypertension, and other factors on patient prognosis was analyzed.\n                    <jats:bold>Results<\/jats:bold>\n                    : Both groups demonstrated significant PTA improvements following treatment, with a statistically significant difference (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). The hearing recovery effective rate in the control group was 42.1%, while that of the experimental group reached 70.5%, with a statistically significant difference between the groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Most patients experienced notable hearing improvements 1\u2009week after treatment, with some patients still showing progress 2\u2009weeks post-treatment. Multifactor analysis revealed that hypertension and onset days were associated with treatment outcomes.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Secondary treatment remains clinically significant for patients with SSHL who have not achieved a satisfactory response or show no clear improvement following initial treatment. The presence of hypertension and delayed treatment are negative factors related to treatment efficacy.\n                  <\/jats:p>","DOI":"10.1177\/01455613231181711","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T02:18:49Z","timestamp":1688005129000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of Clinical Efficacy and Influencing Factors of Nerve Growth Factor (NGF) Treatment for Sudden Sensorineural Hearing Loss"],"prefix":"10.1177","volume":"105","author":[{"given":"Zhengrong","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China"},{"name":"Department of Otolaryngology, Central People\u2019s Hospital of Zhanjiang, Zhanjiang, Guangdong, China"},{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minqian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"},{"name":"Department of Hearing and Speech Science, Guangzhou Xinhua College, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hearing and Speech Science, Guangzhou Xinhua College, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"},{"name":"Department of Hearing and Speech Science, Guangzhou Xinhua College, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Central People\u2019s Hospital of Zhanjiang, Zhanjiang, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7193-9598","authenticated-orcid":false,"given":"Haidi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"},{"name":"Department of Hearing and Speech Science, Guangzhou Xinhua College, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819859883"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198405000-00014"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1128133"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4301-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.3144"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.09.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.06.004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813500754"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00106-4"},{"key":"e_1_3_2_11_2","first-page":"310","article-title":"An extended study: protective effects of nerve growth factor in neomycin-induced auditory neural degeneration","volume":"163","author":"Shah SB","year":"1995","unstructured":"Shah SB, Gladstone HB, Williams H, et al. 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