{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:06:15Z","timestamp":1777561575958,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020J01097"],"award-info":[{"award-number":["2020J01097"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022J01215"],"award-info":[{"award-number":["2022J01215"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Project of the Treatment of Auditory System Dysfunction in Aging Population","award":["2020YFC2005204"],"award-info":[{"award-number":["2020YFC2005204"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this study is to determine whether thrombin time (TT) could be used as diagnostic biomarkers and predict the prognosis for sudden sensorineural hearing loss (SSNHL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sixty-one patients diagnosed with SSNHL and 65 people who underwent physical examination were recruited. Data on the patient\u2019s background, clinical course, and laboratory findings were collected. SSNHL patients were divided into the effective and ineffective groups according to the hearing recovery from the treatment and were assessed by binary logistic regression. Receiver-operating characteristic (ROC) analysis was carried out for the best discriminating cutoff value of the biomarker with the corresponding sensitivity and specificity was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The SSNHL group exhibited prolonged TT (19.11 \u00b1 1.12 seconds) compared to the control group (17.58 \u00b1 2.18 seconds,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Binary logistic regression analysis found a significant positive association between TT and SSNHL and was observed with an odds ratio (OR) 1.769 [95% confidence interval (CI) 1.344-2.330,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001] in the unadjusted model. Even after adjustment using the variables included in the multivariate models, TT was significantly predictive of SSNHL. A TT cutoff value of 17.65 seconds provides optimal separation between patients with SSNHL and controls in the ROC analysis [Area Under the Curve (AUC) 0.773, 95% CI 0.689-0.856; sensitivity, 0.918; and specificity, 0.569]. TT in the effective group of SSNHL patients was shorter (18.76 \u00b1 1.06 seconds) than that in the ineffective group (19.43 \u00b1 1.09 seconds,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .018). The cutoff value of TT as progress predictors was 19.85 seconds. The TT &lt; 19.85 seconds showed an effective rate 59.09% (26\/44) higher than 17.65% (3\/17) of TT \u2265 19.85 seconds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>TT is a potential biomarker of SSNHL and is independently associated with the prognosis of patients with SSNHL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613231190704","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:31:35Z","timestamp":1693189895000},"page":"236-243","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Thrombin Time is a Diagnostic Biomarker of Sudden Sensorineural Hearing Loss and Predicts the Prognosis"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-5736","authenticated-orcid":false,"given":"Junying","family":"Chen","sequence":"first","affiliation":[{"name":"Central laboratory, Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"},{"name":"National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Fujian Provincial Geriatric Hospital, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuna","family":"Huang","sequence":"additional","affiliation":[{"name":"National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China"},{"name":"Department of Clinical Research and Translation Center, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"He","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Fujian Provincial Hospital South Branch, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Lin","sequence":"additional","affiliation":[{"name":"National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China"},{"name":"Department of Otolaryngology, Fujian Institute of Otorhinolarynglolgy, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819859883"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1084713811408349"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419828759"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05469-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.01.023"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28231"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31816fdcb4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.3144"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7165257"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5152\/balkanmedj.2015.15216"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.06.018"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6159720"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94931-w"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200205000-00013"},{"issue":"2","key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1177\/019459987908700226","article-title":"Hypercoagulability as a cause of sudden neurosensory hearing loss","volume":"87","author":"Zajtchuk JT","year":"1979","unstructured":"Zajtchuk JT, Falor WHJr, Rhodes MF. 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