{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:06:17Z","timestamp":1777561577997,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical research on health industry of Shanghai Health Commission","award":["20214Y0025"],"award-info":[{"award-number":["20214Y0025"]}]},{"name":"research of Shanghai Pudong District Health Commission","award":["PW2022A-41"],"award-info":[{"award-number":["PW2022A-41"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The objective of this study is to evaluate the incidence and associated factors for early death (ED) in hypopharynx squamous cell carcinomas (SCC) patients.\n                    <jats:bold>Materials and Methods:<\/jats:bold>\n                    Patients were extracted from the Surveillance, Epidemiology and End Results database between 2004 and 2014. The ED (survival time \u22643 months) rate was calculated, and associated risk factors were evaluated by the logistic regression models.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 2659 patients were analyzed and 307 (11.5%) patients died within 3 months after cancer diagnosis, among whom 243 (79.2%) patients died from cancer-specific cause. In univariate analyses, advanced age, divorced\/single\/widowed (DSW), non-Caucasian, advanced T classification, distant metastasis, and no surgery were significantly associated with ED (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05, respectively). Multivariate analyses showed that advanced age, DSW, advanced T classification, distant metastasis, and no surgery were significantly associated with all-cause and cancer-specific ED.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Our results showed that a total of 11.5% patients with hypopharynx SCC suffered ED, among whom 79.2% patients died from cancer-specific cause. Predictors of ED are primarily related to age \u226562 years, advanced T classification, distant metastasis, and no surgery but also include unmarried status; better prognostic and predictive tools for select ED patients in larger sample size are needed.\n                  <\/jats:p>","DOI":"10.1177\/01455613231192282","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T02:29:46Z","timestamp":1691980186000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Early Death Incidence and Prediction Among Patients With Hypopharynx Squamous Cell Carcinomas"],"prefix":"10.1177","volume":"105","author":[{"given":"Yujiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China"},{"name":"Shanghai Key Laboratory of Radiation Oncology, Shanghai, China"},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China"},{"name":"Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-8180","authenticated-orcid":false,"given":"Chaosu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China"},{"name":"Shanghai Key Laboratory of Radiation Oncology, Shanghai, China"},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China"},{"name":"Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21384"},{"key":"e_1_3_3_3_2","first-page":"1","article-title":"Epidemiology of hypopharyngeal cancer","volume":"83","author":"Bradley PJ","year":"2019","unstructured":"Bradley PJ. Epidemiology of hypopharyngeal cancer. 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