{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:06:57Z","timestamp":1777561617399,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate the graft success rate and hearing outcome of modified cartilage inlay graft technique for repairing large perforations under local anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Prospective case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>We performed a prospective study in 31 patients with large perforations who underwent endoscopic local anesthesia-based modified cartilage inlay graft technique with no raising of the squamous epithelium and no rimming of the perforation margins. The graft outcomes and complications were evaluated at 6 and 24\u2009months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirty-one patients (31 ears) were included in this study. The mean operation time was 42.3\u2009\u00b1\u20092.6 (ranged 36-51) minutes. The visual analog scale pain scores at intraoperative and 2 and 48\u2009hours postoperatively were, respectively, 2.6\u2009\u00b1\u20090.6, 1.4\u2009\u00b1\u20090.2, and 0.6\u2009\u00b1\u20090.1. The graft success rate was 100.0% (31\/31) at 6\u2009months after surgery. However, only 25 (80.6%, 25\/31) patients completed a 2-year follow-up and performed a temporal bone CT examination; re-perforation was seen in 2 patients, the graft success rate was 92.0% (23\/25). CT revealed the well-developed pneumatization of the mastoids and middle ear in all the patients. Nevertheless, 1 (1\/25, 8.0%) patient developed a graft epithelial inclusion cyst, which was removed by endoscope in the outpatient setting. The mean preoperative air bone gap (ABG) was 23.1\u2009\u00b1\u20094.3\u2009dB, while the mean postoperative ABG after 6\u2009months was 14.9\u2009\u00b1\u20092.6\u2009dB; the difference between these values was significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05; Wilcoxon\u2019s signed-rank test), and the functional success rate was 93.5% (29\/31).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Endoscopic modified cartilage \u201cinlay\u201d graft technique with no raising the squamous epithelium and no rimming the perforation is a minimally invasive technique with a short operative time and satisfying success rate for closure of large perforations under local anesthesia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613231200821","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T03:25:26Z","timestamp":1695612326000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Local Anesthesia-Based Modified Cartilage \u201cInlay\u201d Graft Myringoplasty for Repairing Large Perforation"],"prefix":"10.1177","volume":"105","author":[{"given":"Meixia","family":"Wu","sequence":"first","affiliation":[{"name":"Central Sterile Supply Department, Yiwu Central Hospital, Jinhua, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-9033","authenticated-orcid":false,"given":"Zhengcai","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Wenzhou Medical University Affiliated Yiwu Hospital, Yiwu, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2019.02.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24221"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2019.03.015"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556131709600818"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2017.07.003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.08.007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003141"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06913-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13863"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27599"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0834-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.879"},{"key":"e_1_3_2_14_2","article-title":"Microscopic over-under versus medial tympanoplasty for larger tympanic membrane perforations","author":"Zhang X","unstructured":"Zhang X, Ji C, Li A, Xu Z, Zhang X. Microscopic over-under versus medial tympanoplasty for larger tympanic membrane perforations. Ear Nose Throat J. 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